High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis

Table 4 Univariate and multivariate Cox regression analyses of clinical and radiological parameters affecting recurrence-free survival in patients with resected cholangiocarcinoma

Subgroup	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	aHR (95%CI)	P value
Age ≥ 65 years	0.968 (0.510-1.840)	0.921	-	-
Male	1.163 (0.617-2.193)	0.641	-	-
Tumor size ≥ 5 cm	1.605 (0.816-3.157)	0.170	-	-
LN metastasis	1.484 (0.803-2.746)	0.208	-	-
Resection margin	1.070 (0.563-2.034)	0.837	-	-
MD tumor (WD as a reference)	1.385 (0.686-2.796)	0.363	-	-
PD tumor (WD as a reference)	0.290 (0.037-2.247)	0.236	-	-
CA19-9 ≥ 37 U/mL	1.355 (0.724-2.534)	0.342	-	-
High PrPC	1.985 (1.071-3.679)	0.029	1.985 (1.071-3.679)	0.029

HR: Hazard ratio; CI: Confidence interval; aHR: Adjusted hazard ratio; LN: Lymph node; MD: Moderately differentiated; WD: Well-differentiated; PD: Poorly differentiated; CA19-9: Carbohydrate antigen 19-9; PrP^C: Cellular prion protein.