High cellular prion protein expression in cholangiocarcinoma: A marker for early postoperative recurrence and unfavorable prognosis

Table 3 Univariate and multivariate Cox regression analyses of clinical and radiological parameters affecting overall survival in patients with resected cholangiocarcinoma

Subgroup	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	aHR (95%CI)	P value
Age ≥ 65 years	0.764 (0.357-1.635)	0.488	-	-
Male	1.496 (0.658-3.400)	0.336	-	-
Tumor size ≥ 5 cm	2.609 (1.218-5.591)	0.014	2.448 (1.130-5.306)	0.023
LN metastasis	2.222 (1.039-4.753)	0.040	2.633 (1.168-5.936)	0.020
Resection margin	2.036 (0.954-4.349)	0.066	-	-
MD tumor (WD as a reference)	1.321 (0.552-3.158)	0.532	-	-
PD tumor (WD as a reference)	1.073 (0.222-5.180)	0.930	-	-
CA19-9 ≥ 37 U/mL	2.248 (0.954-5.296)	0.064	-	-
High PrPC	2.187 (1.015-4.709)	0.046	2.877 (1.260-6.572)	0.012

HR: Hazard ratio; CI: Confidence interval; aHR: Adjusted hazard ratio; LN: Lymph node; MD: Moderately differentiated; WD: Well-differentiated; PD: Poorly differentiated; CA19-9: Carbohydrate antigen 19-9; PrP^C: Cellular prion protein.