Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis

doi:10.4240/wjgs.v17.i3.100820

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Mar 27, 2025 (publication date) through Feb 24, 2025

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Mar 27, 2025; 17(3): 100820
Published online Mar 27, 2025. doi: 10.4240/wjgs.v17.i3.100820

Table 5 Diagnostic performance of tumor marker panel with and without fecal occult blood test panel, %

Panel	AUC (95%CI)	Sensitivity	Specificity	PPV	NPV
CEA + CA19-9 + CA72-4	0.87 (0.81-0.93)	81.2	77.8	78.5	80.6
CEA + CA19-9 + CA72-4 + FOBT	0.91 (0.86-0.96)	86.5	82.3	83.1	85.8

AUC: Area under the curve; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; CEA: Carcinoembryonic antigen; CA: Cancer antigen; FOBT: Fecal occult blood test.

Citation: Li M, Yuan DH, Yang Z, Lu TX, Zhang L. Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis. World J Gastrointest Surg 2025; 17(3): 100820
URL: https://www.wjgnet.com/1948-9366/full/v17/i3/100820.htm
DOI: https://dx.doi.org/10.4240/wjgs.v17.i3.100820