Retrospective analysis of preoperative tumor marker levels in rectal cancer patients: Implications for diagnosis

Table 3 Diagnostic performance of tumor markers, %

Marker/combination	AUC (95%CI)	Sensitivity	Specificity	PPV	NPV
CEA	0.78 (0.73-0.83)	68.4	82.1	79.5	71.8
CA19-9	0.71 (0.65-0.77)	52.8	85.3	78.2	64.1
CA72-4	0.69 (0.63-0.75)	48.0	87.6	79.3	62.4
CA125	0.65 (0.59-0.71)	42.4	86.9	76.2	60.1
CA15-3	0.61 (0.55-0.67)	36.8	88.5	76.1	58.3
AFP	0.57 (0.51-0.63)	22.4	92.8	75.6	54.9
CEA + CA19-9	0.84 (0.79-0.89)	76.8	79.3	78.7	77.5
CEA + CA72-4	0.82 (0.77-0.87)	74.4	80.6	79.3	75.9
CEA + CA19-9 + CA72-4	0.87 (0.83-0.91)	81.2	77.8	78.5	80.6

AUC: Area under the curve; CI: Confidence interval; PPV: Positive predictive value; NPV: Negative predictive value; CEA: Carcinoembryonic antigen; CA: Cancer antigen; AFP: Alpha-fetoprotein.