Value of brief hematological characteristics in differentiating carcinoembryonic-antigen-negative colorectal cancer from benign colorectal diseases

Table 3 The receiver operating characteristic curve assay for hematological parameters

Indicators	AUC (95%CI)	P value	Cut-off value	Sensitivity (%)	Specificity (%)	Youden index
CEA (ng/mL)	0.601 (0.511-0.691)	0.031	1.54	77.03	44.30	0.21
HRR	0.796 (0.727-0.865)	< 0.001	9.42	58.11	86.08	0.44
LRR	0.660 (0.572-0.747)	0.001	0.13	70.27	65.82	0.36
PLR	0.653 (0.565-0.740)	0.001	150.20	72.97	59.49	0.32
HRR + CEA	0.799 (0.730-0.868)	< 0.001		62.16	86.08	0.48
HRR + PLR	0.808 (0.741-0.875)	< 0.001		82.43	68.35	0.51
LRR + CEA	0.673 (0.589-0.759)	< 0.001		68.92	63.29	0.32
PLR + CEA	0.655 (0.569-0.741)	< 0.001		75.68	50.63	0.26
HRR + PLR + LRR + CEA	0.807 (0.740-0.874)	< 0.001		85.14	64.56	0.50

CEA: Carcinoembryonic antigen; HRR: Hemoglobin-to-red blood cell distribution width ratio; LRR: Lymphocyte-to-red blood cell distribution width ratio; PLR: Platelet-to-lymphocyte ratio; AUC: Area under the receiver operating characteristic curve.