Long-term survival outcomes of duodenal adenocarcinoma: A cohort study with 15-year single-center experience

Table 2 Uni- and multivariate analysis for overall survival

Characteristics	Univariate analysis		Multivariate analysis
	Hazard ratio	P value	Hazard ratio	P value
Age (years; ≥ 65 vs < 65 = 1.00)	1.01 (0.99-1.02)	0.24
Gender, female (vs male = 1.00)	0.80 (0.54-1.21)	0.30
CA199 (U/mL; ≥ 37 vs < 37 = 1.00)	2.92 (1.96-4.33)	< 0.001	1.10 (0.60-2.01)	0.76
Radical operation (vs without radical operation = 1.00)	4.912 (2.98-8.11)	< 0.001
AJCC stage IV (vs AJCC stage I-III = 1.00)	3.04 (2.40-3.86)	< 0.001	4.75 (2.70-8.47)	< 0.001
Postoperative complications (vs without postoperative complications = 1.00)	1.22 (0.77-1.95)	0.40
Pancreatic invasion (vs without Pancreatic invasion = 1.00)	5.07 (2.91-8.85)	< 0.001	2.68 (1.41-5.11)	0.003
Poorly differentiation (vs medium-high differentiation = 1.00)	1.88 (1.17-3.00)	0.009
KRAS mutation (vs KRAS wild type = 1.00)	1.24 (0.35-4.29)	0.73
dMMR/MSI-H (vs PMMR/MSS = 1.00)	0.51 (0.12-2.11)	0.35
Her-2 positive (vs Her-2 negative = 1.00)	1.87 (0.68-5.13)	0.23
Adjuvant therapy (vs without adjuvant therapy = 1.00)	2.52 (1.23-5.15)	0.01	2.71 (1.30-5.62)	0.008

AJCC: American Joint Committee on Cancer.