Preoperative serum total bilirubin-albumin ratio as a prognostic indicator in patients with hepatitis-related cirrhosis after splenectomy

Table 3 Univariable and multivariable analyses of risk factors for overall survival

Variable	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Age > 50 years	0.571 (0.277-1.177)	0.129
Gender (male/female)	2.209 (1.064-4.585)	0.033	2.464 (0.668-9.097)	0.176
Smoking (yes/no)	0.712 (0.294-1.726)	0.453
Drinking (yes/no)	0.377 (0.086-1.658)	0.197
Ascites (yes/no)	1.681 (0.505-5.593)	0.397
Hepatitis B infection (yes/no)	1.150 (0.250-5.285)	0.858
Platelet count (< 30 × 109/L)	1.181 (0.547-2.546)	0.672
Hemoglobin (< 120 g/L)	1.340 (0.555-3.231)	0.515
ALT (> 40 U/L)	0.473 (0.232-0.964)	0.039	0.687 (0.168-2.803)	0.600
AST (> 40 U/L)	0.526 (0.256-1.081)	0.080	0.284 (0.043-1.886)	0.193
B/A ratio (high/low)	3.804 (1.834-7.891)	< 0.001	5.350 (1.109-25.807)	0.037
Albumin (< 35 g/L)	2.141 (1.032-4.442)	0.041	1.133 (0.252-5.093)	0.871
Total bilirubin (> 17 μmol/L)	0.489 (0.205-1.170)	0.108
PT (> 17 s)	0.453 (0.212-0.967)	0.041	0.615 (0.129-2.941)	0.542
APTT (> 45 s)	1.016 (0.461-2.238)	0.968
Fibrinogen (< 2 mg/dL)	0.627 (0.305-1.290)	0.205
INR (> 1.2)	0.675 (0.264-1.728)	0.413
AFP (> 20 mg/L)	1.462 (0.314-6.912)	0.629
Child-Pugh score (C vs A)	0.340 (0.125-0.924)	0.297
Child-Pugh score (B vs A)	0.189 (0.048-0.741)	0.017	0.579 (0.042-8.022)	0.684
ALBI 3 vs ALBI 1	3.241 (1.029-10.209)	0.045	1.023 (0.023-45.884)	0.991
ALBI 2 vs ALBI 1	4.500 (1.014-19.963)	0.048	2.386 (0.246-23.142)	0.453
MELD score (≥ 10)	1.577 (0.679-3.660)	0.289
Estimated blood loss ≥ 470 mL	0.369 (0.099-1.372)	0.137
Intraoperative transfusion (yes/no)	0.141 (0.018-1.112)	0.063	0.758 (0.070-8.175)	0.819
Spleen volume ≥ 1426 mm3	0.891 (0.415-1.913)	0.768
Spleen size ≥ 158 mm	0.933 (0.375-2.318)	0.881
Portal vein thrombosis (yes/no)	8.701 (1.160-65.261)	0.035	1.177 (0.106-13.095)	0.894
CCI > 30	0.965 (0.444-2.096)	0.928

OR: Odds ratio; CI: Confidence interval; ALT: Alanine aminotransferase; AST: Aspartate transaminase; B/A ratio: Total bilirubin-albumin ratio; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; AFP: Alpha fetoprotein; ALBI: Albumin-bilirubin grade; MELD: Model for end-stage liver disease; CCI: Comprehensive complication index.