Preoperative serum total bilirubin-albumin ratio as a prognostic indicator in patients with hepatitis-related cirrhosis after splenectomy

Table 1 Clinical characteristics of 257 cirrhosis patients with high and low serum total bilirubin-albumin ratio, n (%)

Variable	Median (range) (n = 257)	High B/A group (> 0.87) (n = 64)	Low B/A group (≤ 0.87) (n = 193)	P value
Gender (male)	188 (73.15)	47 (73.44)	141 (73.06)	0.953
Age (≥ 50 years)	85 (33.07)	22 (34.38)	63 (32.64)	0.798
Coexisting conditions
Drinking	30 (11.67)	5 (7.81)	25 (12.95)	0.267
Smoking	60 (23.35)	16 (25.00)	44 (22.80)	0.718
Hypertension	4 (1.56)	0 (0.00)	4 (2.07)	0.575
Diabetes	18 (7.00)	3 (4.69)	15 (7.77)	0.574
Hepatitis B virus infection	241 (93.77)	63 (98.44)	178 (92.23)	0.130
Severe gastro-esophageal varices (> 6 mm)	120 (46.69)	33 (51.56)	87 (45.08)	0.368
Laboratory tests
Leucocytes (109/L)	2.66 (0.60-59.00)	2.67 (0.97-12.30)	2.66 (0.60-59.00)	0.992
Platelet count (< 30 × 109/L)	71 (27.63)	30 (46.88)	41 (21.24)	< 0.001
Hemoglobin (< 120 g/L)	196 (76.26)	42 (65.63)	154 (79.79)	0.021
ALT (> 40 U/L)	89 (34.63)	26 (40.63)	63 (32.64)	0.245
AST (> 40 U/L)	122 (47.47)	39 (60.94)	83 (43.01)	0.013
Albumin (< 35 g/L)	123 (47.86)	42 (65.63)	81 (41.97)	0.001
Total bilirubin (> 17 μmol/L)	181 (70.43)	64 (100.00)	117 (60.62)	< 0.001
BUN (mmol/L)	4.93 (2.08-11.51)	4.81 (2.08-10.40)	4.96 (2.09-11.51)	0.545
Creatinine (μmol/L)	65.98 (15.00-187.60)	61.94 (15.00-114.54)	67.36 (32.00-187.60)	0.033
PT (> 17 s)	77 (29.96)	38 (59.38)	39 (20.21)	< 0.001
APTT (> 45 s)	75 (29.18)	33 (51.56)	42 (21.76)	< 0.001
Fibrinogen (mg/dL)	1.89 (0.60-5.36)	1.69 (0.60-3.56)	1.96 (0.76-5.36)	0.001
INR (> 1.2)	173 (67.32)	55 (85.94)	118 (61.14)	< 0.001
AFP (mg/L)	10.95 (0.76-69.31)	17.95 (1.12-69.31)	8.76 (0.76-125.8)	0.007
HB/CV-DNA/RNA (104 IU/mL)	1267.2 (0.1-149100.0)	84.0 (0.1-729)	1632.8 (0.1-149100.0)	0.484
Child-Pugh score
Child A	81 (31.52)	2 (3.13)	79 (40.93)	< 0.001
Child B	157 (61.09)	45 (70.31)	112 (58.03)
Child C	19 (7.39)	17 (26.56)	2 (1.04)
ALBI grade
1 (≤ -2.60)	40 (15.56)	1 (1.56)	39 (20.21)	< 0.001
2 (-2.60 to -1.39)	202 (78.60)	51 (79.69)	151 (78.24)
3 (> -1.39)	15 (5.84)	12 (18.75)	3 (1.55)
MELD score (≥ 10)	48 (18.68)	27 (42.19)	21 (10.88)	< 0.001

B/A ratio: Total bilirubin-albumin ratio; ALT: Alanine aminotransferase; AST: Aspartate transaminase; BUN: Blood urea nitrogen; PT: Prothrombin time; APTT: Activated partial thromboplastin time; INR: International normalized ratio; AFP: Alpha fetoprotein; HBV: Hepatitis B virus; HCV: Hepatitis C virus; ALBI: Albumin-bilirubin grade; MELD: Model for end-stage liver disease; HB/CV: Hepatitis B/C virus.