Retrospective Study
Copyright ©The Author(s) 2024.
World J Gastrointest Surg. Sep 27, 2024; 16(9): 2910-2924
Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.2910
Table 4 Cox regression analysis of the effects of clinicopathological factors on the recurrence-free survival of patients
VariablesUnivariate analysis
Multivariate analysis
HR (95%CI)
P value
HR (95%CI)
P value
Age (year)1.001 (0.980-1.023)0.931
Cardiocerebrovascular disease1.225 (0.844-1.777)0.285
Preoperative biliary drainage0.679 (0.343-1.342)0.265
Platelet (109/L)1.002 (0.999-1.005)0.229
WBC (109/L)0.978 (0.906-1.056)0.565
Neutrophil (109/L)0.999 (0.914-1.091)0.982
Monocyte (109/L)0.839 (0.409-1.720)0.632
Lymphocyte (109/L)0.695 (0.516-0.936)0.017a0.834 (0.478-1.456)0.523
Hemoglobin (g/L)1.001 (0.991-1.011)0.872
Albumin (g/dL)1.019 (0.989-1.051)0.221
TB (μmol/L)1.001 (0.999-1.002)0.469
CA19-9 (U/mL) (> 69.3)1.000 (1.000-1.000)0.970
PLR (> 159.8)1.003 (1.001-1.005)0.001a1.000 (0.995-1.004)0.811
NLR (> 2.8)1.129 (1.024-1.245)0.015a0.895 (0.694-1.155)0.393
LMR (> 1.1)0.888 (0.798-0.989)0.030a0.922 (0.771-1.101)0.368
NMR (> 11.5)0.992 (0.959-1.026)0.624
ABR (> 3.7)0.938 (0.792-1.112)0.463
SII (> 496.6)1.001 (1.000-1.001)0.002a1.001 (1.000-1.002)0.146
ICPI (> 445.4)1.001 (1.000-1.002)0.001a0.894 (0.784-1.020)0.096
APRI (> 1.7)1.032 (0.866-1.229)0.726
SIRI (> 1.1)1.080 (0.972-1.200)0.001a0.949 (0.752-1.199)0.000a
Tumor size (cm) (> 1.8)1.258 (1.013-1.561)0.038a1.144 (0.887-1.475)0.229
Venous invasion type1.503 (0.819-2.759)0.1891.577 (0.566-4.391)0.383
aP < 0.05.
PLR: Platelet-to-lymphocyte ratio; NLR: Neutrophil to lymphocyte ratio; LMR: Lymphocyte to monocyte ratio; NMR: Neutrophil-to-monocyte ratio; APRI: Aspartate transaminase-to-platelet; ABR: Albumin to bilirubin ratio; ICPI: Inflammation-combined prognostic index; SII: Systemic immune-inflammation index; SIRI: Systemic inflammatory response index; HR: Hazard ratio; CI: Confidence interval; WBC: White blood count; TB: Total bilirubin; CA19-9: Carbohydrate antigen 19-9.