Personalized treatment of perihilar cholangiocarcinoma based on tumor genetic and molecular characteristics

Table 1 Molecular targets in perihilar cholangiocarcinoma

Genes	Full name	The role in tumor
PKM2	Pyruvate kinase M2	Oncogene
PRR11	Proline rich 11	Oncogene
TCF7	Transcription factor 7	Oncogene
HMGB1	High mobility group box 1	Oncogene
HDGF	Hepatoma-derived growth factor	Oncogene
PRDX1	Peroxiredoxin 1	Oncogene
DKK1	Dickkopf WNT signaling pathway inhibitor 1	Oncogene
ADAM17	A disintegrin and metalloproteinase 17	Oncogene
Il-8	Interleukin 8	Oncogene
CUL4A	Cullin 4A	Oncogene
MTSS1	Metastasis associated lung adenocarcinoma transcript 1	Tumor suppressor gene
RECK	Reversion-inducing-cysteine-rich protein with kazal motifs	Tumor suppressor gene
SPARCL1	Secreted protein acidic and rich in cysteine-like 1	Tumor suppressor gene
MALAT1	Metastasis associated lung adenocarcinoma transcript 1	Tumor suppressor gene