Primary coexisting adenocarcinoma of the colon and neuroendocrine tumor of the duodenum: A case report and review of the literature

Table 1 Clinical and pathological data of the patient

Feature	Colon adenocarcinoma	Neuroendocrine tumor
Tumor size	6 cm × 4 cm × 1 cm	9 mm
Lymph node invasion	- (0/20)	Not applicable
Fat tissue invasion	+	-
Perineural invasion	+	-
Vascular invasion	+	-
Lymphatic vessel invasion	+	-
Muscularis propria invasion	+	-
Serosal invasion	+	-
Resection margins	-	-
Tumor necrosis	+	-
P53	90% (+)	10% (+)
Ki-67	70% (+)	2% (+)
Mitoses/2 mm2	> 20	1
Immunocytochemistry	Syn (-), MLH1 (+), MSH2 (+), MSH6 (+), PMS2 (+), BRAFV600E (-), CD34 (+), D2-40 (+)	CK (+), CK7 (+), CgA (+), Syn (+), NSE (+)
Grade of the cancer	High grade (G3)	Low grade (G1)
TNM stage	pT4apN0pM0	pT1pN0pM0
Astler-Coller classification[1]	B	Not applicable
AJCC clinical stage[2]	IIB	I

AJCC: American Joint Committee on Cancer; BRAFV600E: B-Raf proto-oncogene, serine/threonine kinase 600E; CgA: Chromogranin A; CK: Cytokeratin; CK7: Cytokeratin 7; Ki-67: Antigen Ki-67; MLH1: MutL homologue 1; MLH3: MutS homologue 3; MSH2: MutS homologue 2; MSH6: MutS homologue 6; NSE: Neuron-specific enolase; PMS2: PMS1 homolog 2 mismatch repair system component; Syn: Synapsin; TNM: Tumor, node, metastasis classification of malignant tumors.