Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway

doi:10.4240/wjgs.v16.i7.2296

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jul 27, 2024; 16(7): 2296-2307
Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2296

Table 1 Effects of Yangyin Huowei mixture on body mass, diet quantity, and fecal water content of rats (mean ± SD)

Group	Intervention time	n	Body mass (g)	Water intake (mL)	Food intake (g)	Fecal water content (g/%)
Blank control	Week 0	10	418.32 ± 22.36^b^,^c	47.38 ± 2.59^b	32.36 ± 2.96	72.23 ± 5.03^b
	Week 2	10	423.16 ± 20.88^b^,^c	47.55 ± 3.68^b	30.88 ± 1.79	70.75 ± 3.67^b
	Week 4	10	451.22 ± 21.84^b^,^c	46.69 ± 3.28^b	29.84 ± 2.55	69.71 ± 4.25^b
	Week 6	10	472.12 ± 22.36^b^,^c	53.72 ± 2.80^b	28.36 ± 2.51	68.23 ± 3.18^b
	Week 8	10	499.24 ± 22.75^b^,^c	54.07 ± 4.74^b	32.75 ± 2.79	72.62 ± 3.53^b
Model	Week 0	10	378.75 ± 18.78^a	62.47 ± 5.79^a	26.84 ± 1.94^a	66.71 ± 5.70^a
	Week 2	10	399.32 ± 18.68^a	60.92 ± 3.76^a^,^c	28.26 ± 2.37^a	58.13 ± 4.95^a^,^c
	Week 4	10	410.27 ± 18.35^a	63.50 ± 6.33^a^,^c	30.65 ± 2.35^a	60.52 ± 4.69^a^,^c
	Week 6	10	418.16 ± 20.07^a	56.47 ± 4.02^a^,^c	25.78 ± 2.01^a	61.65 ± 3.72^a^,^c
	Week 8	10	439.72 ± 17.20^a^,^c	65.90 ± 4.79^a^,^c	27.78 ± 2.08^a^,^c	57.65 ± 5.01^a^,^c
Low-dose YYHWM	Week 0	11	370.24 ± 17.58^a	60.58 ± 4.68^a	27.40 ± 1.44^a	65.27 ± 4.18^a
	Week 2	11	389.76 ± 16.91^a	53.04 ± 5.77^b	30.64 ± 3.26^a	70.51 ± 5.23^b
	Week 4	11	402.16 ± 19.02^a	52.69 ± 4.70^b	28.78 ± 2.27^a	68.65 ± 5.09^b
	Week 6	11	424.92 ± 15.33^a	40.69 ± 4.13^b	26.68 ± 2.61^a	66.55 ± 4.93^b
	Week 8	11	448.38 ± 16.91^a	52.01 ± 4.09^b	26.35 ± 3.38^a^,^c	66.22 ± 3.52^b^,^c
Medium-dose YYHWM	Week 0	11	368.71 ± 16.86^a	61.83 ± 3.49^a	27.07 ± 2.19^a	66.94 ± 2.75^a
	Week 2	11	379.73 ± 16.58^a	52.69 ± 3.82^b	31.72 ± 2.07^a	71.59 ± 4.21^b
	Week 4	11	398.18 ± 14.81^a	40.69 ± 4.21^b	31.75 ± 1.71^a	71.62 ± 2.57^b
	Week 6	11	429.22 ± 16.05^a	52.01 ± 3.58^b	28.91 ± 1.77^a	72.78 ± 2.78^b
	Week 8	11	458.16 ± 13.04^a^,^c	42.41 ± 4.28^b	29.02 ± 2.39^a	68.89 ± 5.62^b
High-dose YYHWM-H	Week 0	11	370.19 ± 15.67^a	62.63 ± 3.97^a	27.33 ± 2.57^a	67.20 ± 6.22^a
	Week 2	11	397.72 ± 16.15^a	48.80 ± 2.75^b	26.91 ± 3.06^a	71.78 ± 4.22^b
	Week 4	11	419.24 ± 16.24^a	49.32 ± 3.34^b	29.86 ± 1.75^a	69.73 ± 5.45^b
	Week 6	11	438.43 ± 22.51^a^,^b^,^c	47.09 ± 4.97^b	30.58 ± 3.15^a	70.45 ± 5.77^b
	Week 8	11	455.82 ± 21.74^a^,^b^,^c	48.29 ± 3.58^b	28.81 ± 2.24^a	68.68 ± 4.82^b
Vitacoenzyme	Week 0	11	365.41 ± 23.80^a	63.30 ± 2.95^a	26.05 ± 1.86^a	65.92 ± 5.92^a
	Week 2	11	379.43 ± 14.28^a	56.87 ± 3.64^b	28.04 ± 1.68^a	67.91 ± 4.44^b
	Week 4	11	395.63 ± 22.03^a	43.21 ± 2.97^b	25.67 ± 1.94^a	65.54 ± 3.40^b
	Week 6	11	422.27 ± 16.99^a	45.10 ± 4.62^b	29.15 ± 2.53^a	69.02 ± 5.31^b
	Week 8	11	444.35 ± 17.74^a^,^b	45.27 ± 3.32^b	30.24 ± 3.03^a	70.11 ± 4.27^b

^aP < 0.05 compared with blank control group.

^bP < 0.05 compared with model group.

^cP < 0.05 compared with model group.

YYHWM: Yangyin Huowei mixture.

Citation: Xie SS, Zhi Y, Shao CM, Zeng BF. Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10/JAK1/STAT3 pathway. World J Gastrointest Surg 2024; 16(7): 2296-2307
URL: https://www.wjgnet.com/1948-9366/full/v16/i7/2296.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i7.2296