Effectiveness of colonoscopy, immune fecal occult blood testing, and risk-graded screening strategies in colorectal cancer screening

Table 3 Comparison of detection rates of advanced tumors

Screening stage	Progressive tumors (%, 95%CI)			Colonoscopy group/FIT group
	Colonoscopy group	FIT group	Graded screening group	OR (95%CI)	P value
Baseline screening
Overall	2.76 (2.29-3.32)	0.15 (0.94-1.42)	0.65 (1.39-1.96)	2.45 (1.84-3.26)	< 0.001
Proximal colon	1.36 (1.05-1.78)	0.53(0.39-0.71)	0.62 (0.47-0.83)	2.62 (1.74-3.97)	< 0.001
Distal colon and rectum	1.73 (1.36-2.19)	0.80 (0.62-1.02)	0.17 (0.95-1.43)	2.19 (1.54-3.12)	< 0.001
Baseline screening + 1st follow-up screening
Overall	2.76 (2.29-3.32)	0.67 (1.41-1.98)	0.91 (1.63-2.24	1.68 (1.29-2.18)	< 0.001
Proximal colon	1.36 (1.05-1.78)	0.72 (0.55-0.95)	0.73 (0.56-0.94)	1.91 (1.30-2.79)	0.001
Distal colon and rectum	1.73 (1.36-2.19)	1.15 (0.94-1.42	1.35 (1.12-1.63)	0.50 (1.08-2.06)	0.014
Baseline screening + 1st follow-up screening + 2nd follow-up screening
Overall	2.76 (2.29-3.32)	2.17 (1.87-2.52)	2.35 (2.04-2.71)	0.30 (1.01-1.65)	0.037
Proximal colon	1.36 (1.05-1.78)	0.96 (0.77-1.20)	0.90 (0.71-1.13)	1.46 (1.05-2.05)	0.031
Distal colon and rectum	1.76 (1.45-2.18)	1.48 (1.23-1.77)	1.65 (1.39-1.96)	1.19 (0.88-1.61)	0.244
Screening stage	Colonoscopy group compared to grading screening group			Graded screening group/FIT group
	OR (95%CI)		P value	OR (95%CI)	P value
Baseline screening
Overall	1.69 (1.29-2.20)		< 0.001	1.45 (1.11-1.92)	0.008
Proximal colon	2.21 (1.49-3.28)		0.001	1.19 (0.79-1.82)	0.409
Distal colon and rectum	1.46 (1.06-2.02)		0.021	1.49 (1.08-2.08)	0.017
Baseline screening + 1st follow-up screening
Overall	1.45 (1.12-1.87)		0.004	1.15 (0.91-1.47)	0.245
Proximal colon	1.9 (1.29-2.76)		0.001	1.01 (0.70-1.47)	0.941
Distal colon and rectum	1.26 (0.92-1.72)		0.148	1.18 (0.88-1.57)	0.266
Baseline screening + 1st follow-up screening + 2nd follow-up screening
Overall	1.19 (0.93-1.51)		0.156	1.09 (0.88-1.34)	0.440
Proximal colon	1.56 (1.10-2.20)		0.012	0.94 (0.68-1.29)	0.681
Distal colon and rectum	1.06 (0.79-1.42)		0.680	1.12 (0.87-1.44)	0.384

FIT: Fecal occult blood test; CI: Confidence interval.