Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

Table 4 Multivariate logistic regression analyses for the incidence of post-hepatectomy liver failure in the subsample of hepatitis B virus-related hepatocellular carcinoma patients

Variable	Overall patients (n = 1301)		Not receiving AVT (n = 941)
	OR (95%CI)	P value	OR (95%CI)	P value
Sex, male vs female	1.48 (0.74-2.99)	0.27	1.37 (0.63-2.99)	0.43
Age, year (continuous)	1.04 (1.01-1.06)	0.002	1.03 (1.00-1.05)	0.046
Hypertension, yes vs no	0.90 (0.56-1.45)	0.667	0.88 (0.51-1.50)	0.63
Diabetes, yes vs no	0.74 (0.44-1.24)	0.245	0.73 (0.40-1.32)	0.296
BMI, kg/m2 (continuous)	0.96 (0.91-1.02)	0.228	0.96 (0.90-1.03)	0.304
WBC count, 109/L (continuous)	0.93 (0.82-1.05)	0.241	0.95 (0.83-1.09)	0.465
Hemoglobin, g/L (continuous)	1.02 (1.01-1.03)	0.007	1.01 (1.00-1.03)	0.067
PLT, 109/L (continuous)	0.99 (0.99-1.00)	0.001	0.99 (0.99-1.00)	0.003
ALT, U/L (continuous)	1.00 (0.99-1.01)	0.939	0.99 (0.98-1.00)	0.179
AST, U/L (continuous)	1.01 (1.00-1.01)	0.328	1.01 (1.00-1.02)	0.127
γ-GT, U/L (continuous)	1.00 (1.00-1.00)	0.030	1.00 (1.00-1.00)	0.103
Alb, g/L (continuous)	0.92 (0.87-0.98)	0.005	0.92 (0.86-0.98)	0.007
ALP, U/L (continuous)	1.00 (1.00-1.00)	0.852	1.00 (1.00-1.01)	0.963
TBil, μmol/L (continuous)	1.07 (1.03-1.10)	< 0.001	1.07 (1.04-1.11)	< 0.001
BUN, mmol/L (continuous)	0.89 (0.76-1.04)	0.129	0.94 (0.79-1.12)	0.48
Cr, μmol/L (continuous)	1.00 (0.99-1.02)	0.578	1.00 (0.98-1.02)	0.853
FIB, g/L (continuous)	0.95 (0.82-1.10)	0.463	0.96 (0.82-1.13)	0.624
PT, second (continuous)	1.00 (0.65-1.56)	0.991	1.08 (0.65-1.79)	0.778
INR (continuous)	8.82 (0.07-1159.35)	0.382	2.91 (0.01-820.09)	0.711
AFP, > 400 vs ≤ 400 ng/mL	1.23 (0.82-1.86)	0.318	1.19 (0.75-1.88)	0.459
HBeAg positivity, yes vs no	0.98 (0.64-1.50)	0.920	1.00 (0.62-1.61)	0.999
Cirrhosis, yes vs no	1.70 (1.13-2.55)	0.011	1.70 (1.08-2.69)	0.022
No. of tumor > 1, yes vs no	0.72 (0.45-1.15)	0.174	0.82 (0.49-1.37)	0.452
Tumor diameter, mm (continuous)	1.01 (1.00-1.02)	0.010	1.01 (1.00-1.01)	0.286
Open surgery, yes vs no	0.91 (0.70-1.17)	0.445	0.98 (0.74-1.32)	0.911
Major hepatectomy, yes vs no	2.71 (1.72-4.29)	< 0.001	2.94 (1.76-4.90)	< 0.001
Blood loss > 400 mL, yes vs no	1.25 (0.78-2.00)	0.347	1.48 (0.88-2.48)	0.141
Transfusion, yes vs no	1.04 (0.56-1.90)	0.912	1.02 (0.52-1.98)	0.963
CSPH, yes vs no	1.28 (0.70-2.34)	0.416	1.21 (0.59-2.50)	0.608
Child-Pugh grade, A vs B	0.92 (0.24-3.50)	0.898	0.54 (0.11-2.58)	0.437
AVT, yes vs no	0.61 (0.38-0.98)	0.039	-	-
HBV DNA level, high vs low	-		2.61 (1.50-4.53)	0.001

WBC: White blood cell; PLT: Platelet count; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase; Alb: Albumin; ALP: Alkaline phosphatase; TBil: Total bilirubin; BUN: Blood urea nitrogen; Cr: Creatinine; FIB: Fibrinogen; PT: Prothrombin time; INR: International normalized ratio; AFP: Alpha-fetoprotein; HBeAg: Hepatitis B e antigen; CSPH: Clinically significant portal hypertension; AVT: Antiviral Treatment; HBV: Hepatitis B virus; OR: Odds ratio.