Association of preoperative antiviral treatment with incidences of post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma

Table 3 Logistic regression analysis of the post-hepatectomy liver failure in hepatitis B virus-related hepatocellular carcinoma patients (n = 1301)

Variable	Univariate		Multivariate
	OR (95%CI)	P Value	OR (95%CI)	P Value
Sex, male vs female	1.83 (1.05-3.18)	0.033	1.62 (0.80-3.30)	0.181
Age, year (continuous)	1.02 (1.00-1.03)	0.061	1.04 (1.01-1.06)	0.002
Hypertension, yes vs no	0.73 (0.49-1.09)	0.118	0.88 (0.53-1.47)	0.579
Diabetes, yes vs no	0.73 (0.48-1.13)	0.156	0.75 (0.45-1.28)	0.292
BMI, kg/m2 (continuous)	0.97 (0.93-1.03)	0.319	0.97 (0.91-1.03)	0.296
WBC count, 109/L (continuous)	0.89 (0.81-0.99)	0.024	0.95 (0.83-1.08)	0.398
Hemoglobin, g/L (continuous)	1.01 (1.00-1.02)	0.249	1.02 (1.00-1.03)	0.013
PLT, 109/L (continuous)	0.99 (0.99-1.00)	< 0.001	0.99 (0.99-1.00)	0.001
ALT, U/L (continuous)	1.01 (1.00-1.01)	0.001	1.00 (0.99-1.00)	0.534
AST, U/L (continuous)	1.02 (1.01-1.02)	< 0.001	1.01 (1.00-1.02)	0.261
γ-GT, U/L (continuous)	1.00 (1.00-1.01)	< 0.001	1.00 (1.00-1.00)	0.046
Alb, g/L (continuous)	0.88 (0.84-0.92)	< 0.001	0.94 (0.89-0.99)	0.024
ALP, U/L (continuous)	1.00 (1.00-1.01)	0.003	1.00 (1.00-1.00)	0.999
TBil, μmol/L (continuous)	1.08 (1.06-1.11)	< 0.001	1.07 (1.04-1.10)	< 0.001
BUN, mmol/L (continuous)	0.89 (0.78-1.00)	0.059	0.88 (0.76-1.03)	0.123
Cr, μmol/L (continuous)	1.00 (0.98-1.01)	0.536	1.00 (0.99-1.02)	0.634
FIB, g/L (continuous)	0.93 (0.82-1.05)	0.223	0.95 (0.82-1.10)	0.476
PT, second (continuous)	1.57 (1.33-1.86)	< 0.001	1.03 (0.66-1.60)	0.913
INR (continuous)	196.32 (32.04-1202.99)	< 0.001	5.45 (0.04-755.25)	0.501
AFP, > 400 vs ≤ 400 ng/mL	1.77 (1.27-2.47)	0.001	1.16 (0.77-1.78)	0.477
HBeAg positivity, yes vs no	1.03 (0.71-1.48)	0.881	0.85 (0.55-1.32)	0.475
Cirrhosis, yes vs no	1.76 (1.27-2.44)	0.001	1.66 (1.10-2.49)	0.015
No. of tumor > 1, yes vs no	0.89 (0.59-1.35)	0.595	0.71 (0.45-1.14)	0.160
Tumor diameter, mm (continuous)	1.01 (1.01-1.02)	< 0.001	1.01 (1.00-1.02)	0.020
Open surgery, yes vs no	0.73 (0.58-0.91)	0.006	0.93 (0.71-1.20)	0.555
Major hepatectomy, yes vs no	2.95 (2.10-4.16)	< 0.001	2.36 (1.48-3.76)	< 0.001
Blood loss > 400 mL, yes vs no	2.20 (1.56-3.09)	< 0.001	1.28 (0.80-2.05)	0.303
Transfusion, yes vs no	2.17 (1.40-3.39)	0.001	1.04 (0.56-1.91)	0.913
CSPH, yes vs no	2.28 (1.48-3.52)	< 0.001	1.38 (0.75-2.52)	0.3
Child-Pugh grade, A vs B	4.88 (1.83-13.01)	0.002	0.88 (0.22-3.48)	0.856
AVT, yes vs no	0.51 (0.33-0.77)	0.001	0.88 (0.53-1.47)	0.624
HBV DNA level, high vs low	3.27 (2.26-4.73)	< 0.001	2.08 (1.10-3.93)	< 0.001

WBC: White blood cell; PLT: Platelet count; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase; Alb: Albumin; ALP: Alkaline phosphatase; TBil: Total bilirubin; BUN: Blood urea nitrogen; Cr: Creatinine; FIB: Fibrinogen; PT: Prothrombin time; INR: International normalized ratio; AFP: Alpha-fetoprotein; HBeAg: Hepatitis B e antigen; CSPH: Clinically significant portal hypertension; AVT: Antiviral Treatment; HBV: Hepatitis B virus; OR: Odds ratio.