Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

Table 4 Univariable and multivariable Cox regression analyses of risk factors for post-transjugular intrahepatic portosystemic shunt overt hepatic encephalopathy

	Univariable Cox		Multivariable Cox
	HR (95%CI)	P value	HR (95%CI)	P value
Age (≥ 60 yr)	1.762 (1.043-3.230)	0.049	1.473 (0.834-3.929)	0.118
Gender	0.854 (0.449-1.575)	0.618
BMI (≥ 24.0)	0.689 (0.331-1.329)	0.288
Etiology (HBV)	1.799 (0.945-3.321)	0.065
Child-Pugh score	1.259 (0.587-2.470)	0.525
MELD score	1.279 (0.682-2.482)	0.451
Spleen volume	0.537 (0.283-0.986)	0.049	0.494 (0.234-0.929)	0.042
WBC, 109/L	1.129 (0.616-2.095)	0.696
PLT, 109/L	0.936 (0.512-1.707)	0.828

Cox: Cox proportional hazards model; TIPS: Transjugular intrahepatic portosystemic shunt; OHE: Overt hepatic encephalopathy; HR: Hazard ratio; BMI: Body mass index; HBV: Hepatitis B virus; MELD: Model for end-stage liver disease; WBC: White blood cells; PLT: Platelets.