Spleen volume is associated with overt hepatic encephalopathy after transjugular intrahepatic portosystemic shunt in patients with portal hypertension

Table 3 Comparison of laboratory data and imaging parameters by overt hepatic encephalopathy stage

	Non-OHE (n = 99)	OHE/2 (n = 18)	OHE/3+4 (n = 19)	P value
WBC, 109/L	4.05 ± 3.44	2.51 ± 1.76	4.01 ± 2.44	0.1056
PLT, 109/L	78.61 ± 68.29	75.53 ± 75.37	74.96 ± 50.93	0.9579
INR	1.54 ± 1.39	1.38 ± 0.16	1.45 ± 0.23	0.8172
ALT, U/L	27.16 ± 29.84	17.29 ± 9.22	45.81 ± 78.55	< 0.05
AST, U/L	35.91 ± 30.42	26.66 ± 19.07	74.35 ± 161.60	< 0.05
ALB, g/L	35.21 ± 29.03	33.20 ± 4.87	32.03 ± 5.72	0.8144
TBIL, μmol/L	35.50 ± 39.82	28.60 ± 23.45	41.71 ± 31.00	0.4455
Urea, mmol/L	7.10 ± 9.17	9.78 ± 21.02	6.00 ± 3.30	0.4998
CRE, μmol/L	90.79 ± 127.20	66.29 ± 17.34	60.07 ± 16.12	0.3309
Spleen length, mm	150.90 ± 27.74	141.10 ± 35.44	143.00 ± 27.09	0.2619
Spleen volume, cm3	901.30 ± 471.90	882.30 ± 704.60	697.60 ± 281.00	< 0.05
Liver volume, cm3	1120.00 ± 360.80	1070.00 ± 456.00	1153.00 ± 534.60	0.1891
Liver/spleen volume	2.14 ± 3.07	2.59 ± 2.41	1.66 ± 1.08	0.5066

Data are the mean ± SD, or median (interquartile range). OHE: Overt hepatic encephalopathy; WBC: White blood cells; PLT: Platelets; INR: International normalized ratio; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ALB: Albumin; TBIL: Total bilirubin; CRE: Creatinine.