Application value of indocyanine green fluorescence imaging in guiding sentinel lymph node biopsy diagnosis of gastric cancer: Meta-analysis

Table 2 Meta-subgroup analysis of the sensitivity-based bivariable mixed effects model

Influencing factor	Number	Sensitivity (95%CI)	P value
Optical imaging			< 0.001
Near infrared imaging	10	0.98 (0.96-1.00)
Fluorescence imaging	7	0.73 (0.56-0.91)
Image time			< 0.001
20 minutes after injection	10	0.98 (0.96-1.00)
Immediately after injection	5	0.70 (0.54-0.86)
Average number of SLNS detected			0.010
≥ 4	12	0.96 (0.90-1.00)
< 4	3	0.68 (0.20-1.00)
Pathological staining			< 0.001
IHC + HE	7	0.99 (0.98-1.00)
HE	10	0.84 (0.70-0.98)
Injection site			< 0.001
Submucosal injection	14	0.98 (0.95-1.00)
Subserous injection	2	0.40 (0.18-0.62)
ICG concentration (g/L)			0.010
5	12	0.83 (0.80-0.89)
0.5	3	0.98 (0.93-1.00)
Operation for gastric cancer			0.460
Laparotomy	8	0.95 (0.86-1.00)
Laparoscopic surgery	9	0.96 (0.88-1.00)
Cleaning method			0.200
Lymph node regional dissection	14	0.96 (0.89-1.00)
Lymph node dissection	3	0.96 (0.87-1.00)
Clinical stage of tumor			0.200
cT1	13	0.96 (0.92-1.00)
cT2-3	4	0.72 (0.41-1.00)
Tumor diameter (mm)			0.160
≤ 30	8	0.96 (0.91-1.00)
> 30	3	0.81 (0.64-0.98)

SLN: Sentinel lymph node; ICG: Indocyanine green; IHC: Immunohistochemical; HE: Hematoxylin-eosin staining; cT: Clinical T stage of the tumor.