Effect of high-protein peptide-based formula compared with isocaloric isonitrogenous polymeric formula in critically ill surgical patient

doi:10.4240/wjgs.v16.i6.1765

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Jun 27, 2024 (publication date) through Jun 29, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Clinical Trial

World J Gastrointest Surg. Jun 27, 2024; 16(6): 1765-1774
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1765

Table 2 Baseline characteristics of study participants, n (%)/mean ± SD

	Peptide-based formula (n = 9)	Standard formula (n = 10)	P value
Demographic
Age (yr)	60.1 ± 21.6	49.1 ± 26.0	0.333
Gender (Male)	7 (77.8)	9 (90.0)	0.466
Weight (kg)	66.2 ± 14.3	62.6 ± 10.4	0.533
BMI (kg/m²)	24.2 ± 3.1	22.4 ± 3.8	0.275
GCS score	10.7 ± 3.0	10.0 ± 3.1	0.864
SOFA score	4.0 ± 2.0	4.2 ± 2.0	0.769
¹Nutrition status assessment
Risk of malnutrition	4 (44.4)	3 (30.0)	0.752
Mild malnutrition	4 (44.4)	5 (50.0)
Moderate malnutrition	0 (0.0)	1 (10.0)
Severe malnutrition	1 (11.1)	1 (10.0)
Biochemistry
Hemoglobin (g/dL)	9.8 ± 2.4	10.1 ± 1.8	0.793
White blood cells count (× 10³/μL)	14.8 ± 4.2	15.0 ± 7.5	0.955
Platelets count (× 10³/μL)	218.8 ± 112.7	175.5 ± 85.5	0.253
Neutrophils	84.3 ± 8.5	83.5 ± 5.8	0.826
Monocytes	6.3 ± 3.5	7.2 ± 3.8	0.513
Total lymphocytes count (cell/μL)	1267.1± 1164.8	1006.0 ± 1005.6	0.288
Blood urea nitrogen (mg/dL)	22.3 ± 8.7	21.3 ± 20.6	0.327
Creatinine (mg/dL)	1.1 ± 0.4	1.0 ± 0.9	0.102
Urine urea nitrogen	12.0 ± 6.4	15.4 ± 22.2	0.441
GFR (mL/min/1.73 m²)	74.7± 31.6	103.5 ± 35.8	0.082
Fasting plasma glucose (mg/dL)	128.0 ± 26.7	128.1 ± 49.1	0.374
Alkaline phosphatase (U/L)	92.1 ± 41.2	96.3 ± 64.6	0.859
Aspartate transaminase (U/L)	84.5 ± 52.0	104.3 ± 66.5	0.501
Alanine transaminase (U/L)	32.5 ± 26.0	86.8 ± 99.8	0.154
Nutritional status
Albumin (g/dL)	2.6 ± 0.6	2.5 ± 0.5	0.821
Prealbumin (mg/dL)	10.2 ± 5.3	14.1 ± 8.2	0.236
Retinol binding protein (mg/dL)	2.1 ± 1.7	2.0 ± 1.3	1.000

¹Nutrition status were assessed with Bhumibol Nutrition Triage which is endorsed by Society of Parenteral and Enteral Nutrition of Thailand. NT-1 (score 0-4): Normal or risk of malnutrition; NT-2 (score 5-7): Mild malnutrition; NT-3 (score 8-10): Moderate malnutrition; NT-4 (score >10): Severe malnutrition.

BMI: Body mass index; GCS: Glasgow coma scale; SOFA: Sequential organ failure assessment; GFR: Glomerular filtration rate.

Citation: Sumritpradit P, Shantavasinkul PC, Ungpinitpong W, Noorit P, Gajaseni C. Effect of high-protein peptide-based formula compared with isocaloric isonitrogenous polymeric formula in critically ill surgical patient. World J Gastrointest Surg 2024; 16(6): 1765-1774
URL: https://www.wjgnet.com/1948-9366/full/v16/i6/1765.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i6.1765