Optimal extent of lymphadenectomy improves prognosis and guides adjuvant chemotherapy in esophageal cancer: A propensity score-matched analysis

Table 2 Univariate analysis for overall survival

Prognostic factors		P value	HR (95%CI)
Age		0.576	1 (0.99-1.01)
Maximal tumor diameter		0.038	1.01 (1-1.01)
NRLN		0.049	0.83 (0.68-1)
Sex (ref male)		0.634	0.95 (0.76-1.18)
Tumor location (ref upper)
	Middle	0.065	0.71 (0.49-1.02)
	Lower	0.051	0.65 (0.43-1)
T (ref T1)
	T2	0.028	1.78 (1.07-2.99)
	T3	< 0.001	2.8 (1.74-4.52)
	T4	< 0.001	2.71 (1.65-4.44)
N (ref N0)
	N1	< 0.001	2.04 (1.64-2.53)
	N2	< 0.001	2.35 (1.82-3.02)
	M3	< 0.001	3.38 (2.45-4.65)
G (ref G1)
	G2	0.006	1.57 (1.14-2.15)
	G3	0.002	1.81 (1.25-2.61)
Venous thrombus (ref negative)	Positive	< 0.001	2.1 (1.68-2.63)
Perineurial Invasion (ref negative)	Positive	< 0.001	1.79 (1.41-2.29)
Adjuvant chemotherapy (ref no)	Yes	0.009	1.27 (1.06-1.52)

NRLN: Number of removed lymph nodes; HR: Hazards regression; CI: Confidence interval.