Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature

Figure 2 Histopathologic features in neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma. A: The neuroendocrine carcinoma (NEC) showed a nested organoid growth pattern [hematoxylin and eosin (HE), × 100]; B: The NEC cells were round or oval, hyperchromatic nuclei and scant cytoplasm (HE, × 400); C: Immunohistochemically, the NEC cells were positive for synaptophysin(HE, × 400); D: Immunohistochemically, the NEC cells were positive for chromogranin A (HE, × 400); E: The distal cholangiocarcinoma (dCCA) cells arranged in irregular tubular and papillary structures (HE, × 100); F: Immunohistochemically, the dCCA cells were positive for cytokeratin 19 (HE, × 400).