Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature

Table 3 Comparison of gene mutations in the two primary bile duct tumours

Gene	LCNEC	dCCA
ERBB2	14.10%, exon17, c.2033G>A, p.R678Q	3.70%, exon17, c.2033G>A, p.R678Q
	10.80%, exon17, c.1970C>T, p.A657V
ERBB3	20.10%, exon3, c.310G>A, p.V104M	3.60%, exon3, c.310G>A, p.V104M
LCE1F	43.40%, exon2, c.244C>T, p.R82W	41.70%, exon2, c.244C>T, p.R82W
MSH6	47.80%, exon5, c.3173-3C>G	47.30%, exon5, c.3173-3C>G
	18.00%, exon6, c.3514dup, p.R1172fs
FCAMR	47.00%, exon4, c.250C>T, p.R84W	47.90%, exon4, c.250C>T, p.R84W
BRAF	No	1.30%, exon11, c.1391G>T, p.G464V
CREBBP	45.10%, exon28, c.4711G>A, p.A1571T	52.90%, exon28, c.4711G>A, p.A1571T
ARID1A	17.20%, exon5, c.2077C>T, p.R693*	No
	17.20%, exon20, c.5842_5843del, p.S 1948fs
KMT2C	13.30%, exon46, c.11878C>T, p.R3960	No
	19.80%, exon36, c.5668C>T, p.R1890
KMT2D	21.30%, exon12, c.3318del, p.S1107fs	No
KRAS	18.50%, exon2, c.38G>A, p.G13D	No
CDKN2A	22.20%, exon2, c.238C>T, p.R80	No
ATR	19.30%, exon7, c.1544G>A, p.R515H	No
NTRK1	15.30%, exon11, c.1330C>T, p.R444W	No
CDC73	12.40%, exon6, c.439C>T, p.R147C	No
FOXP1	29.40%, exon12, c.952G>A, p.E318K	No
FBXW7	30.10%, exon10, c.1514G>A, p.R505H	No
MAP3K1	25.10%, exon3, c.746G>A, p.R249H	No
CTNNA1	13.50%, exon7, c.943G>A, p.G315R	No
PRKDC	15.30%, exon73, c.10241C>T, p.T3414M	No
RUNX1T1	23.10%, exon8, c.1084G>A, p.A362T	No
RIC8A	21.30%, exon3, c.568C>T, p.R190C	No
CBL	8.90%, exon14, c.2222C>T, p.A741V	No
KDM5A	15.60%, exon26, c.4400G>A, p.R1467Q	No
	19.80%, exon23, c.3470G>A, p.R1157H
RB1	15.10%, exon8, c.763C>T, p.R255*	No
	15.30%, exon18, c.1735C>T, p.R579*
TP53	2.20%, exon5, c.473G>A, p.R158H	No
BCOR	15.10%, exon4, c.1754G>T, p.R585M	No
STAG2	19.60%, exon9, c.775C>T, p.R259*	No
BCORL1	21.80%, exon4, c.1279G>A, p.A427T	No
	18.10%, exon8, c.4258C>T, p.R1420*

LCNEC: Large cell neuroendocrine carcinoma; dCCA: Distal cholangiocarcinoma.