Neuroendocrine carcinoma of the common hepatic duct coexisting with distal cholangiocarcinoma: A case report and review of literature

Table 2 Comparison of neuroendocrine-non-neuroendocrine neoplasm and pure neuroendocrine carcinoma in the extrahepatic biliary tract

	MiNEN	Pure NEC
Number of cases	19	29
Age, yr	70.47 ± 8.67	64.07 ± 14.88
Sex
Male	15	17
Female	4	12
Location
CHD	2	8
CBD	15	5
CHD + CBD	2	16
Symptom
Jaundice/pruritus	15	24
Abdominal pain	8	8
Anorexia/nauseas/vomit/fatigue/weight loss/ fever	9	3
Size, mm	26.63 ± 12.22	30.15 ± 15.08
Ki-67 index, %	62.12 ± 20.61	69.42 ± 20.75
Treatment
SR	17	12
SR + chemo/radio	2	12
Chemo/radio	0	2
Metastasis
Liver	7	9
Lymph node	0	8
Lung	3	2
Bone	1	3
Brain	0	3
Peritoneal/pleural/local	2	3

MiNEN: Mixed neuroendocrine-non-neuroendocrine neoplasm; NEC: Neuroendocrine carcinoma; CHD: Common hepatic duct; CBD: Common bile duct; SR: Surgical resection; Chemo: Chemotherapy; Radio: Radiotherapy.