Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

doi:10.4240/wjgs.v16.i5.1395

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. May 27, 2024; 16(5): 1395-1406
Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1395

Table 3 Correlations between c-mesenchymal-epithelial transition factor protein expression and clinicopathological characteristics of colorectal cancer patients, n (%)

Characteristic	C-MET IHC				P value
Characteristic	0/1+ (n = 54)	2+ (n = 112)	3+ (n = 39)	Total (n = 205)	P value
Gender					0.525
Male	33 (61.1)	58 (51.8)	21 (53.8)	112 (54.6)
Female	21 (38.9)	54 (48.2)	18 (46.2)	93 (45.4)
Age (yr)					0.138
≥ 60	33 (61.1)	51 (45.4)	22 (56.4)	106 (51.7)
< 60	21 (38.9)	61 (54.5)	17 (43.6)	99 (48.3)
Primary site					0.805
Colon	38 (70.4)	77 (68.8)	25 (64.1)	140 (68.3)
Rectum	16 (29.6)	35 (31.3)	14 (35.9)	65 (31.7)
Tumor type					0.656
Exophytic type	39 (72.2)	81 (72.3)	31 (79.5)	151 (73.7)
Ulcerative type	15 (27.8)	31 (27.7)	8 (20.5)	54 (26.3)
LVI					0.941
Present	17 (31.5)	34 (30.4)	13 (33.3)	64 (31.2)
Absent	37 (68.5)	78 (69.6)	26 (66.7)	141 (68.8)
PNI					0.897
Present	15 (27.8)	33 (29.5)	10 (25.6)	58 (28.3)
Absent	39 (72.2)	79 (70.5)	29 (74.4)	147 (71.7)
EMVI					0.252
Present	5 (9.3)	21 (18.8)	5 (12.8)	31 (15.1)
Absent	49 (90.7)	91 (81.3)	34 (87.2)	174 (84.9)
LNM					0.002
Present	18 (33.0)¹	56 (50.0)¹	25 (64.1)¹	89 (43.4)
Absent	36 (67.0)¹	56 (50.0)¹	14 (35.9)¹	116 (56.6)
PDC					0.188
Present	35 (64.8)	87 (77.7)	30 (76.9)	152 (74.1)
Absent	19 (35.2)	25 (22.3)	9 (23.1)	53 (25.9)
TB					0.148
BD1	34 (63.0)	66 (58.9)	17 (43.6)	117 (57.1)
BD2/3	20 (37.0)	46 (41.1)	22 (56.4)	88 (42.9)
Histologic differentiation					0.541
P/D or mucinous	17 (31.5)	27 (24.1)	9 (23.1)	53 (25.9)
W/D or M/D	37 (68.5)	85 (75.9)	30 (76.9)	152 (74.1)

¹Each superscript letter denotes a subset of MET mesenchymal-epithelial transition factor immunohistochemistry categories whose column proportions do not differ significantly from each other at the 0.05 level.

MET: Mesenchymal-epithelial transition factor; EMVI: Extramural venous invasion; LNM: Lymph node metastasis; LVI: Lymphovascular invasion; M/D: Moderately differentiated; P/D: Poorly differentiated; PDC: Poorly differentiated clusters; PNI: Perineural invasion; TB: Tumor budding; W/D: Well differentiated.

Citation: Yu QX, Fu PY, Zhang C, Li L, Huang WT. Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer. World J Gastrointest Surg 2024; 16(5): 1395-1406
URL: https://www.wjgnet.com/1948-9366/full/v16/i5/1395.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i5.1395