Mesenchymal-epithelial transition factor amplification correlates with adverse pathological features and poor clinical outcome in colorectal cancer

Table 2 Correlations between polysomy-caused mesenchymal-epithelial transition factor amplification and clinicopathological characteristics of colorectal cancer patients, n (%)

Characteristic	MET FISH			P value
	Positive MET GCN ≥ 5 (n = 28)	Negative MET GCN < 5 (n = 167)	Total (n = 195)
Gender				0.975
Male	15 (53.60)	90 (53.90)	105 (53.80)
Female	13 (12.90)	77 (46.21)	90 (46.20)
Age (yr)				0.085
≥ 60	19 (67.90)	84 (50.30)	103 (52.80)
< 60	9 (32.10)	83 (49.70)	92 (47.20)
Primary site				0.077
Colon	23 (82.10)	109 (65.30)	132 (67.70)
Rectum	5 (17.90)	58 (34.70)	63 (32.30)
Tumor type				0.187
Exophytic type	18 (64.30)	127 (76.00)	145 (74.40)
Ulcerative type	10 (35.70)	40 (24.00)	50 (25.60)
LVI				0.261
Present	11 (39.30)	48 (28.70)	59 (30.30)
Absent	17 (60.70)	119 (71.30)	136 (69.70)
PNI				0.377
Present	10 (35.70)	46 (27.50)	56 (28.70)
Absent	18 (64.30)	121 (72.50)	139 (71.30)
EMVI				0.500
Present	6 (21.40)	24 (14.40)	30 (15.40)
Absent	22 (78.60)	143 (85.60)	165 (84.60)
LNM				< 0.001
Present	21 (75.00)	60 (35.90)	81 (41.50)
Absent	7 (25.00)	107 (64.10)	114 (58.50)
PDC				0.153
Present	24 (85.70)	122 (73.10)	146 (74.90)
Absent	4 (14.30)	45 (26.90)	49 (25.10)
TB				0.020
BD1	10 (35.70)	99 (59.30)	109 (55.9)
BD2/3	18 (64.30)	68 (40.70)	86 (44.10)
Histologic differentiation				0.933
P/D or mucinous	7 (25.00)	43 (25.70)	50 (25.60)
W/D or M/D	21 (75.00)	124 (74.30)	145 (74.40)

MET: Mesenchymal-epithelial transition factor; EMVI: Extramural venous invasion; GCN: Gene copy number; LNM: Lymph node Metastasis; LVI: Lymphovascular invasion; M/D: Moderately differentiated; P/D: Poorly differentiated; PDC: Poorly differentiated clusters; PNI: Perineural invasion; TB: Tumor budding; W/D: Well differentiated.