Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

Table 2 Univariate and multivariate analysis of overall survival

Risk factors	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age (yr)	1.045 (1.037-1.055)	< 0.01a	1.042 (1.033-1.051)	< 0.01a
Sex (male/female)	0.931 (0.770-1.126)	0.461
BMI (kg/m2)	0.952 (0.924-0.981)	0.001a	0.980 (0.952-1.008)	0.161
T2DM (yes/no)	1.231 (0.938-1.617)	0.134
Tumor location (colon/ rectum)	1.179 (0.979-1.421)	0.083
Tumor stage (III/II/I)	2.105 (1.817-2.438)	< 0.01a	1.938 (1.665-2.255)	< 0.01a
Smoking (yes/no)	0.964 (0.795-1.168)	0.706
Drinking (yes/no)	0.884 (0.718-1.089)	0.248
Hypertension (yes/no)	0.926 (0.743-1.154)	0.493
Tumor size (≥ 5 cm/< 5 cm)	1.426 (1.184-1.718)	< 0.01a	1.117 (0.923-1.351)	0.255
CEA (abnormal/normal)	2.185 (1.812-2.633)	< 0.01a	1.393 (1.137-1.707)	0.001a
AFP (abnormal/normal)	1.108 (0.715-1.718)	0.645
CA-199 (abnormal/normal)	2.646 (2.185-3.204)	< 0.01a	1.984 (1.614-2.438)	< 0.01a
Surgical time, min	1.001 (1.000-1.002)	0.069

^aP < 0.05.

BMI: Body mass index; T2DM: Type 2 diabetes mellitus; AFP: Alpha fetoprotein; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 19-9.