Preoperative prognostic nutritional index predicts long-term outcomes of patients with ampullary adenocarcinoma after curative pancreatoduodenectomy

Table 2 Univariate and multivariate analysis of overall survival in patients with ampullary adenocarcinoma

Variate	Univariate analysis			Multivariate analysis
	HR	95%CI	P value	HR	95%CI	P value
Gender (male vs female)	0.882	0.593-1.313	0.537
age (≤ 60 vs > 60)	1.147	0.769-1.713	0.501
Tumor size (≤ 2 vs > 2)	1.142	0.773-1.689	0.504
Tumor differentiation (non-well vs well)	0.667	0.407-1.094	0.109
Lymph nodes resection (< 17 vs ≥ 17)	1.161	0.761-1.771	0.488
Vascular invasion (No vs Yes)	1.318	0.846-2.053	0.222
pT (T1, T2 vs T3, T4)	2.114	1.417-3.153	< 0.001	1.901	1.257-2.876	0.002
pN (N0 vs N1, N2)	2.197	1.454-3.319	< 0.001	1.851	1.209-2.834	0.005
Postoperative complication (No vs Yes)	1.043	0.695-1.567	0.838
Postoperative adjuvant therapy (No vs Yes)	1.432	0.934-2.195	0.100
PNI (< 45.3 vs ≥ 45.3)	0.584	0.393-0.866	0.007	0.569	0.383-0.846	0.005

PNI: Prognostic nutritional index; 95%CI: 95% confidence interval; HR: Hazard ratio.