Blastomas of the digestive system in adults: A review

Table 2 Summary of reported cases of adult hepatoblastoma from recent 10 years (2013-2023)

Ref.	Age/sex	Location	Hepatitis B	Liver cirrhosis	AFP	Metastasis at diagnosis	Histology	Treatment	Follow-up	Recurrence or metastasis
Pagarigan et al[49], 2023	49/F	Right hepatic lobe	HBsAg (+); anti-HBc (+)	Yes	> 50000 ng/mL	No	Mixed	Surgical resection + postoperative chemotherapy	4 months	Recurrence
Ihssan et al[10], 2022	26/F	Right Hepatic lobe	No	No	2275 ng/mL	No	Epithelial (the mixed fetal and embryonic pattern)	Surgical resection	N/A	N/A
Ihssan et al[10], 2022	50/M	Entire liver	No	No	6386 ng/mL	No	Mixed	N/A	N/A	N/A
Park et al[50], 2015	36/F	Right hepatic lobe	HBsAg (+); anti-HBc (+)	Yes	676.5 ng/mL	No	Mixed	Surgical resection + postoperative chemotherapy	5 months	Intraperitoneal metastasis, died
Caso-Maestro et al[51], 2013	27/M	Right hepatic lobe	HBsAg +, HBcAb +, HBeAb +	No	1166000 ng/mL		Mixed	Surgical resection	27 months	Left adrenal recurrence followed by total adrenalectomy; alive
Al-Jiffry et al[33], 2013	22/M	Left hepatic lobe	No	No	Normal	Diaphragm, pericardial, and IVC infiltration	Mixed	Surgical resection	16 d	Died
Cienfuegos et al[52], 2013	37/F	Segment 5 and 6 of the liver	HBsAg +, HBcAb +, HBeAb +	Yes	1556.3 ng/mL	No	Mixed	Surgical resection	10 months	Recurrence and died
Zhang et al[53], 2013	32/F	Left hepatic lobe	No	No	Normal	No	Epithelial, neuroendocrine differentiation	N/A	N/A	N/A
Park et al[50], 2015	36/F	Right hepatic lobe	HBsAg +, HBcAb +, HBeAb +		676.5 ng/mL	No	Mixed	Surgical resection + postoperative chemotherapy	12 months	Left subphrenic area metastasis; died
Celotti et al[54], 2016	68/M	Left hepatic lobe	No	No	1231 ng/mL	Pericardial metastasis	Mixed	Left lobectomy +; diaphragm resection + extended pericardiectomy	21 months	No recurrence
Urdiain et al[55], 2019	65/M	Right hepatic lobe	No	No	N/A	No	Epithelial	Surgical resection	10 months	Recurrence, died
Dave et al[56], 2019	84/M	Left hepatic lobe	N/A	N/A	708 IU/mL	Metastatic to left lower bronchus, left descending pulmonary artery and left descending pulmonary vein	Mixed	N/A	N/A	N/A

AFP: Alpha-fetoprotein; F: Female; M: Male; HBsAg: Hepatitis B surface Antigen; HBcAb: Hepatitis B core antibody; HBeAb: Hepatitis B e-antibody; N/A: Not available; IVC: Inferior vena cava.