Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

Figure 4 The genomic instability-derived long non-coding RNAs signature was verified in the testing set and TCGA set. A: Kaplan–Meier survival analysis of the high-risk and low-risk groups in the testing set; B: Time-dependent receiver operating characteristic (ROC) curves analysis of the genomic instability-derived long non-coding RNAs signature (GILncSig) in the testing set; C: Long non-coding RNAs (LncRNAs) expression patterns, distribution of somatic mutations, UBQLN4 and H2AX expression with increasing GILncSig score in the testing set; D: The boxplots of the distribution of somatic mutations between the high-risk and low-risk groups in the testing group; E: The boxplots of the UBQLN4 expression and the H2AX expression between the high-risk and low-risk groups in the testing group; F: Kaplan–Meier survival analysis of high-risk and low-risk groups in the TCGA set; G: Time-dependent ROC curves analysis of the GILncSig in the TCGA set; H: LncRNA expression patterns, distribution of somatic mutations, UBQLN4 and H2AX expression with increasing GILncSig score in the TCGA set; I: The boxplots of the distribution of somatic mutations, and the expression of UBQLN4, H2AX between the high-risk and low-risk groups in the TCGA group.