Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

Figure 3 Identification of the genomic instability-derived long non-coding RNAs signature in the training set. A: Forest plot: The P value, risk coefficient (HR) of 13 genomic instability (GI)-long non-coding RNAs (LncRNAs) in the training set analyzed by univariate Cox regression were significantly associated with hepatocellular carcinoma prognosis; B: Kaplan–Meier analysis of overall survival in patients with low or high risk according to the GI-derived LncRNAs signature (GILncSig) score in the training set; C: Time-dependent receiver operating characteristic curves analysis of the GILncSig; D: The LncRNA expression patterns, distribution of somatic mutations, UBQLN4 and H2AX expression with increasing GILncSig score; E: Somatic mutations count in the high-risk and low-risk groups for the training set patients. Red represents the high-risk group, and blue represents the low-risk group; F: The boxplots of UBQLN4 expression and H2AX expression between the high-risk and low-risk groups in the training group.