Construction and validation of somatic mutation-derived long non-coding RNAs signatures of genomic instability to predict prognosis of hepatocellular carcinoma

Figure 1 Identification of genomic instability-related long non-coding RNAs in patients with hepatocellular carcinoma. A: The top 20 long non-coding RNAs (LncRNAs) significantly expressed between the genomically unstable (GU) and genomically stable (GS) groups; B: Unsupervised hierarchical clustering analysis was conducted on 374 tumor samples in the TCGA set using 88 differentially expressed LncRNAs. The left orange cluster is the GU-like group, and the right blue cluster is the GS-like group; C: Boxplots of somatic mutations between the GU-like group and GS-like group; D: Boxplots of H2AX expression level in the GU-like group and GS-like group. The expression level of H2AX in the GU-like group is significantly higher than that in the GS-like group. GU: Genomically unstable; GS: Genomically stable.