Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

Figure 1 Analyzing phospholipase A2 gene family in cholangiocarcinoma: Expression patterns and correlations. A: The enrichment levels of the 5 phospholipase A2 (PLA2) gene families include cytosolic PLA2, calcium-independent PLA2, lysosomal PLA2, platelet-activating factor acetylhydrolase, and secreted PLA2; B: The expression level of PLA2 gene family in cholangiocarcinoma (T) and normal tissues adjacent (NAT); C: Correlations between the expression of each PLA2 family member in cholangiocarcinoma; D: Differentially expressed genes between the PLA2 gene family in tumor and normal samples were shown in the volcano plot, with blue dots representing significantly down-regulated genes and red dots representing significantly up-regulated genes.; E-J: The expression levels of PLA2G2A and PLA2G12B in public databases (The Cancer Genome Atlas and the Gene Expression Omnibus) were found in the T and NAT groups. . ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. NAT: Adjacent normal tissues