Preoperative neutrophil-to-lymphocyte ratio predicts symptomatic anastomotic leakage in elderly colon cancer patients: Multicenter propensity score-matched analysis

Table 3 Univariate and multivariate logistic regression analyses of risk factors associated with the occurrence of symptomatic anastomotic leakage after propensity score matching

Variable	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
Gender
Female1
Male	1.37 (0.50-3.72)	0.540
Age (yr)	1.00 (0.91-1.09)	0.949
BMI (kg/m2)	0.98 (0.84-1.15)	0.812
Smoking
No1
Yes	0.77 (0.24-2.44)	0.653
History of abdominal surgery
No1
Yes	1.19 (0.40-3.51)	0.757
Nonsteroidal drug use
No1
Yes	1.55 (0.33-7.31)	0.581
Lung disease
No1
Yes	0.73 (0.26-2.05)	0.551
Hypertension
No1
Yes	0.86 (0.29-2.54)	0.787
Diabetes mellitus
No1
Yes	1.07 (0.29-3.89)	0.923
Neoadjuvant chemotherapy
No1
Yes	3.48 (0.37-33.03)	0.277
Tumor location
Right hemicolon1
Transverse colon	1.53 (0.17-13.61)	0.704
Left hemicolon	1.25 (0.31-4.98)	0.752
Sigmoid colon	0.92 (0.29-2.91)	0.883
ASA classification
< 21
3	1.211 (0.377-3.887)	0.748
Surgical approach
Open1
Laparoscopic	0.65 (0.22-1.94)	0.438
Robotic	1.52 (0.35-6.60)	0.574
Anastomosis
End-to-end anastomosis1
End-lateral anastomosis	1.43 (0.42-4.95)	0.568
Lateral anastomosis	1.56 (0.40-6.07)	0.523
Blood transfusion intraoperatively and within 2 d postoperatively
No1
Yes	2.85 (1.05-7.74)	0.040	2.52 (0.88-7.25)	0.049
T stage
≤ 21
≥ 3	0.822 (0.224-3.014)	0.768
N stage
01
1	1.28 (0.41-4.00)	0.667
2	1.28 (0.33-4.97)	0.725
Tumor diameter (cm)	1.01 (0.81-1.26)	0.931
CEA (ng/mL)	1.00 (0.99-1.01)	0.636
Preoperative hemoglobin (g/L)	1.01 (0.99-1.03)	0.327
Preoperative albumin (g/L)	0.85 (0.75-0.97)	0.013	0.99 (0.73-1.35)		0.946
Preoperative PNI	0.86 (0.76-0.96)	0.010	0.88 (0.66-1.17)		0.380
Preoperative NLR
NLR < 2.661
NLR ≥ 2.66	5.14 (1.44-18.38)	0.012	5.51 (1.50-20.26)		0.010

¹Control group.

BMI: Body mass index; ASA: American Society of Anesthesiologists; CEA: Carcinoembryonic antigen; NLR: Neutrophil-to-lymphocyte ratio; PNI: Prognostic nutritional index; OR: Odds ratio; CI: Confidence interval.