Systemic inflammatory response index is a predictor of prognosis in gastric cancer patients: Retrospective cohort and meta-analysis

Table 3 Univariate and multivariate Cox regression analyses for overall survival in patients with robotic gastrectomy

Variables		Univariate analysis			Multivariate analysis
		HR	95%CI value	P value	HR	95%CI	P value
Gender	Male/female	0.743	0.400-1.379	0.346
Age (yr)		1.05	1.023-1.077	< 0.001	1.067	1.035-1.099	< 0.001
Underlying disease	No/yes	1.307	0.759-2.248	0.334
BMI		0.98	0.915-1.048	0.553
Tumor location				0.264
	Upper third	Ref
	Middle third	0.434	0.117-1.604	0.211
	Lower third	1.13	0.379-2.274	0.733
Tumor dimensions (cm)	< 3/≥ 3	0.494	0.266-0.917	0.025	0.672	0.338-1.338	0.258
Differentiation	Moderate and poor/well	0.047	0.000-11.342	0.275
TNM stage				0.005			0.025
	I	Ref			Ref
	II	3.77	1.264-8.709	0.042	3.03	1.243-7.984	0.047
	III	5.695	2.181-9.845	0.001	5.68	2.161-9.541	0.01
Operation	Subtotal gastrectomy /total gastrectomy	1.423	0.893-2.269	0.138
ASA	I-II/III-IV	1.118	0.535-2.336	0.767
Perioperative transfusion	No/yes	1.58	0.959-2.603	0.073
Blood loss (mL)	> 200 mL/≤ 200 mL	1.763	1.109-2.803	0.016	1.498	0.914-2.458	0.109
Operation time (minutes)		1.001	0.997-1.004	0.938
CA199 (ng/mL)	Negative/positive	1.347	0.780-2.327	0.286
CEA (ng/mL)	Negative/positive	2.473	1.543-3.963	< 0.001	1.266	0.76-2.108	0.365
Postoperative complication	No/yes	4.787	2.846-8.052	< 0.001	7.244	3.780-13.781	< 0.001
Postoperative chemotherapy	No/yes	2.929	1.543-5.562	0.001	1.298	0.649-2.597	0.461
P53	Wild/Mutant	0.728	0.455-1.165	0.186	0.392	0.231-0.663	< 0.001
Ki-67				0.137			0.003
	0%-49%	Ref			Ref
	50%-74%	1.137	0.471-2.743	0.775	2.088	0.822-5.303	0.121
	75%-100%	0.702	0.297-1.661	0.421	0.788	0.321-1.932	0.603
Her-2	Negative/positive	0.321	0.079-1.310	0.113
Lymph node metastasis rate (%)	< 4.6%/≥ 4.6%	5.943	2.845-12.414	< 0.001	2.266	0.897-5.724	0.083
Enteral nutrition time		1.023	0.965-1.186	0.443
Length of hospitalization (days)		1.032	0.995-1.070	0.092
SIRI	≤ 1.38/> 1.38	3.787	2.376-6.034	< 0.001	2.696	1.579-4.404	< 0.001

The bold numbers in the tables are P values with statistical significance (< 0.05). OS: Overall survival; BMI: Body mass index; ASA: American society of anesthesiology; CA199: Carbohydrate antigen 199; CEA: Carcinoembryonic antigen; SIRI: Systemic inflammation response index; TNM: Tumor-node-metastasis.