Influence of donor age on liver transplantation outcomes: A multivariate analysis and comparative study

Table 3 Cox proportional hazards model – all variables and metrics

Variable	Coefficient (95%CI)	Hazard ratio (95%CI)	P value
Donor pre-procurement cardiac arrest (yes)	0.400 (0.027, 0.774)	1.493 (1.028, 2.168)	0.035
Recipient age	0.031 (0.014, 0.049)	1.032 (1.014, 1.050)	< 0.001
Donor CRP	0.001 (0.000, 0.003)	1.001 (0.999, 1.003)	0.055
BAR score	0.031 (-0.001, 0.064)	1.032 (0.999, 1.066)	0.060
Indication for LT-cancer (HCC, CCC)	0.137 (-0.275, 0.548)	1.146 (0.760, 1.730)	0.515
Indication for LT-hepatitis C virus	1.029 (0.510, 1.548)	2.798 (1.665, 4.702)	< 0.001
Indication for LT-re-transplantation	0.593 (0.098, 1.087)	1.809 (1.103, 2.965)	0.019
Indication for LT-miscellaneous	0.307 (-0.190, 0.803)	1.359 (0.827, 2.233)	0.226
Indication for LT-cholestatic disease	-0.371 (-1.168, 0.426)	0.690 (0.311, 1.532)	0.362

The model had no significant transformations and interactions, and the final model is the (linear) main effects model. Donor age was eliminated as insignificant in all previous steps of development. CRP: C-reactive protein; BAR: Balance of Risk; LT: Liver transplantation; HCC: Hepatocellular carcinoma; CCC: Cholangiocarcinoma.