Prognostic value of combined systemic inflammation response index and prognostic nutritional index in colorectal cancer patients

Table 4 Cox regression analysis of PSIRI and overall survival

Variables	Model 1		Model 2		Model 3		Model 4
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
PSIRI
2	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
1	4.00 (2.24-7.13)	< 0.001	3.92 (2.13-7.21)	< 0.001	3.92 (2.13-7.21)	< 0.001	3.56 (1.89-6.71)	0.018
0	13.61 (7.35-25.19)	< 0.001	13.26 (6.76-26.00)	< 0.001	13.26 (6.76-26.00)	< 0.001	9.53 (4.08-22.26)	< .001
PSIRI
2	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
≤ 1	5.60 (3.25-9.64)	< 0.001	5.30 (2.97-9.45)	< 0.001	5.30 (2.97-9.45)	< 0.001	3.77 (2.03-6.98)	< 0.001

Model 1: Crude; Model 2: Adjusted with age and gender; Model 3: Adjusted with Model 2 + body mass index, smoke, and drink; Model 4: Adjusted with Model 3 + T stage, N stage, differentiated degree, nerve invasion, intravascular tumor emboli, carcinoembryonic antigen, neutrophil to lymphocyte ratio, monocyte to lymphocyte ratio, and platelet-to-lymphocyte ratio. HR: Hazard ratio; 95%CI: 95% confidence interval.