Prognostic value of combined systemic inflammation response index and prognostic nutritional index in colorectal cancer patients

Table 2 Univariate and multivariate analysis on the overall survival of prognostic nutritional index and systemic inflammation response index

Variables	Model 1		Model 2		Model 3		Model 4
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
PNI
≥ 47.82	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
< 47.82	3.93 (2.53-6.10)	< 0.001	3.33 (2.08-5.33)	< 0.001	3.33 (2.08-5.33)	< 0.001	2.96 (1.79-4.92)	< 0.001
SIRI
< 1.38	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
≥ 1.38	4.00 (2.61-6.12)	< 0.001	3.78 (2.42-5.92)	< 0.001	3.78 (2.42-5.92)	< 0.001	2.27 (1.26-4.11)	0.007

Model 1: Crude; Model 2: Adjusted with age and gender; Model 3: Adjusted with Model 2 + body mass index, smoke, and drink; Model 4: Adjusted with Model 3 + T stage, N stage, differentiated degree, nerve invasion, intravascular tumor emboli, carcinoembryonic antigen, neutrophil to lymphocyte ratio, monocyte to lymphocyte ratio, and platelet-to-lymphocyte ratio. HR: Hazard ratio; 95%CI: 95% confidence interval; PNI: Prognostic nutritional index; SIRI: Systemic inflammation response index.