Onset and prognostic features of anastomotic leakage in patients undergoing radical surgery after neoadjuvant chemoradiation for rectal cancer

Table 5 Univariate analysis of factors affecting poor prognosis in patients with postoperative anastomotic leakage

Factor	Favorable prognosis group (n = 27)		Unfavorable prognosis group (n = 34)		t/χ2	P value
	Cases	Percentage (%)	Cases	Percentage (%)
Sex
Male	22	81.48	26	76.47	0.225	0.635
Female	5	18.52	8	23.53
Age (years)
< 55	15	55.56	18	52.94	0.041	0.839
≥ 55	12	44.44	16	47.06
Tumor distance from the anus (cm)
< 5	9	33.33	23	67.65	7.105	0.008
≥ 5	18	66.67	11	32.35
Interval between radiotherapy and surgery (weeks)
≥ 8	7	25.93	8	23.53	0.047	0.829
< 8	20	74.07	26	76.47
Prophylactic stoma
Yes	12	44.44	15	44.12	0.001	0.980
No	15	55.56	19	55.88
Hand-sewn anastomosis
Yes	9	33.33	9	26.47	0.341	0.559
No	18	66.67	25	73.53
ISREC classification
Grade A	19	70.37	11	32.35	10.468	0.005
Grade B	5	18.52	20	58.82
Grade C	3	11.11	3	8.82
Fistula location
Anterior wall	4	14.81	5	14.71	7.507	0.057
Posterior wall	14	51.85	26	76.47
Lateral wall	7	25.93	1	2.94
Circumferential	2	7.41	2	5.88

ISREC: Swiss Institute for Experimental Cancer Research.