Risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding

doi:10.4240/wjgs.v16.i11.3437

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 11

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (393)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-3) series.

Item

Count

PDF

HTML

226

Figures (1-2)

Tables (1-3)

Sum=331

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=51

Nov 27, 2024 (publication date) through Nov 28, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Surgery

ISSN

1948-9366

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Study

World J Gastrointest Surg. Nov 27, 2024; 16(11): 3437-3444
Published online Nov 27, 2024. doi: 10.4240/wjgs.v16.i11.3437

Table 1 Demographics and clinical characteristics, n (%)

Variables	Non-hypofibrinogenemia (n = 73)	Hypofibrinogenemia (n = 36)	P value
Age (years)	76.0 (66.5-82.0)	73.0 (57.3-81.0)	0.29
Sex, female	24 (32.9)	22 (61.1)	0.005^a
Body mass index (kg/m²)	20.3 (19.1-21.8)	20.3 (19.2-20.3)	0.183
Total hemocoagulase doses (KU)	3.0 (1-6.5)	5.0 (2.0-11.8)	0.026^a
Treatment duration (days)	2 (1-5)	3 (1-6.8)	0.1
ICU admission	4 (5.5)	8 (22.2)	0.021^a
Total deaths	14 (19.2)	14 (38.9)	0.027^a
Severe blood loss	7 (9.6)	15 (41.7)	0.000^a
Bleeding location
Upper gastrointestinal	25 (34.2)	17 (47.2)	0.190
Small bowel	1 (1.4)	1 (2.8)	1.0
Lower gastrointestinal	5 (6.8)	1 (2.8)	0.667
Unknown site of bleeding	42 (57.5)	17 (47.2)	0.310
Cause of bleeding
Esophagogastric varices	3 (4.1)	10 (27.8)	0.001^a
Malignant neoplasm	21 (28.8)	8 (22.2)	0.467
Peptic ulcer	10 (13.7)	2 (5.6)	0.341
Ischemic bowel disease	3 (4.1)	0 (0)	0.549
Severe infection	22 (30.1)	8 (22.2)	0.384
Unexplained GIB	14 (19.2)	8 (20.2)	0.710
Concomitant drugs
Cephalosporin	12 (16.4)	7 (19.4)	0.697
Carbopenems	10 (13.7)	3 (8.3)	0.618
CSS	48 (65.8)	27 (75.0)	0.327
Vitamin K1	5 (6.8)	3 (8.3)	1.0
Tranexamic acid	4 (5.5)	3 (8.3)	0.876
Transfusion
PRC	17 (23.3)	16 (44.4)	0.024^a
FFP	6 (8.2)	7 (19.4)	0.166
Laboratory tests
Baseline FIB (g/L)	4.11 (3.18-5.44)	2.20 (2.00-2.96)	0.000^a
Post-hemocoagulase FIB (g/L)	3.83 (2.81-5.16)	1.23 (0.67-1.62)	0.000^a
PLT (× 10⁹/L)	202 (137.5-277.5)	122.5 (79-216.75)	0.001^a
WBC (× 10⁹/L)	9.08 (7.11-12.38)	8.00 (5.79-11.51)	0.285
ALT (U/L)	19.00 (14.20-37.78)	20.13 (12.50-34.85)	0.867
AST (U/L)	28.04 (19.90-39.89)	27.89 (20.18-54.28)	0.556
TBil (μmol/L)	11.00 (8.32-20.08)	15.87 (11.51-39.84)	0.003^a

^aP < 0.05.

KU: Klobusitzky unit; ICU: Intensive care unit; GIB: Gastrointestinal bleeding; CSS: Carbazochrome sodium sulfonate; PRC: Packed red cell; FFP: Fresh frozen plasma; FIB: Fibrinogen; PLT: Platelet; WBC: White blood cells; ALT: Alanine transaminase; AST: Aspartate transaminase; ALB: Albumin; TBil: Total bilirubin.

Citation: Zou F, Wu MT, Wang YY. Risk factors for hemocoagulase-associated hypofibrinogenemia in patients with gastrointestinal bleeding. World J Gastrointest Surg 2024; 16(11): 3437-3444
URL: https://www.wjgnet.com/1948-9366/full/v16/i11/3437.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i11.3437