Postoperative serum tumor markers-based nomogram predicting early recurrence for patients undergoing radical resections of pancreatic ductal adenocarcinoma

Figure 3 Receiver operating characteristic curve analysis of the nomogram, and stratified analysis of patients’ outcomes depending on recurrence nomogram score. A: Receiver operating characteristic (ROC) curves of recurrence nomogram score (RNS) 1 [with postoperative serum tumor markers (STMs)] and RNS2 (without postoperative STMs) for predicting early recurrence (ER). The area under the curve (AUC) of RNS1 was greater than the AUC of RNS2 (P = 0.016); B: ROC curves of RNS (with postoperative STMs) for predicting ER in different time intervals. The AUC of RNS decreased with time; C: The stacked plot of both ER and delayed recurrence stratified by RNS. It showed that the ER ratio was significantly higher in high-risk group than in low-risk group (P < 0.001); D: The stacked plot of recurrence sites stratified by RNS. It showed that hepatic metastasis was more frequently observed in high-risk group compared with low-risk group (P = 0.001); E: Kaplan-Meier survival analysis of recurrence free survival (RFS) stratified by RNS. High-risk group had significantly poorer RFS compared with low-risk group. RNS: Recurrence nomogram score; AUC: Area under the curve.