Adjuvant chemotherapy for isolated resectable colorectal lung metastasis: A retrospective study using inverse probability treatment weighting propensity analysis

Table 5 Univariable Cox proportional hazards model for overall survival in the original cohort

Factors		HR (univariable)
Gender	M
	F	0.78 (0.35-1.77, P = 0.555)
Age at primary cancer	≤ 60 years
	> 60 years	1.41 (0.65-3.05, P = 0.381)
Smoking history	No
	Yes	1.11 (0.48-2.55, P = 0.814)
Age lung surgery	≤ 60 years
	> 60 years	0.98 (0.45-2.12, P = 0.956)
Surgical approach for PM	Open
	VATS	0.77 (0.32-1.84, P = 0.556)
Type of resection	Lobectomy
	Sublobar resection	0.47 (0.21-1.04, P = 0.062)
Lymph node dissection	No
	Yes	1.18 (0.55-2.55, P = 0.674)
Positive LN at PM	No
	Yes	0.62 (0.08-4.60, P = 0.642)
Adjuvant chemotherapy	No
	Yes	0.47 (0.20-1.12, P = 0.087)
Primary tumor location	Left colon
	Right colon	0.91 (0.32-2.63, P = 0.863)
	Rectum	0.60 (0.24-1.53, P = 0.288)
CEA levels	≤ 5 ng/mL
	> 5 ng/mL	1.48 (0.66-3.31, P = 0.335)
Number of metastatic lesions	1
	> 1	1.75 (0.73-4.23, P = 0.211)
Bilateral pulmonary nodules	No
	Yes	1.88 (0.44-8.08, P = 0.398)
Tumor size (cm)	≤ 2 cm
	> 2 cm	0.67 (0.29-1.53, P = 0.337)
Prior extra-thoracic metastasis	No
	Yes	1.94 (0.58-6.50, P = 0.283)
DFI	≤ 600
	> 600	0.48 (0.22-1.04, P = 0.063)

CEA: Carcinoembryonic antigen; HR: Hazard ratio; M: Male; F: Female; LN: Lymph nodes; PM: Pulmonary metastases; VATS: Video-assisted thoracoscopic surgery; DFI: Disease-free interval.