Serum nutritional predictive biomarkers and risk assessment for anastomotic leakage after laparoscopic surgery in rectal cancer patients

Table 4 Univariate and multivariate logistic regression analysis of risk factors for anastomotic leakage

Factors	Reference	Univariate			Multivariate
		OR	95%CI	P value	OR	95%CI	P value
PA	Continuous variable	1.721	1.271-2.198	0.021	2.621	1.582-3.812	0.012
ALB	Continuous variable	1.594	1.165-2.063	0.017	3.982	1.927-4.887	0.024
TRF	Continuous variable	1.982	1.366-2.598	0.030	2.109	1.162-2.981	0.031
Gender	0 = male, 1 = female	0.982	0.764-1.175	0.281	/	/	/
Age	0 = < 60, 1 = ≥ 60	1.021	0.835-1.284	0.473	/	/	/
BMI	0 = < 24 kg/m2, 1 = ≥ 24 kg/m2	0.894	0.712-1.092	0.501	/	/	/
Hypertension	0 = No, 1 = Yes	1.123	0.902-1.351	0.124	/	/	/
Diabetes	0 = No, 1 = Yes	1.076	0.863-1.376	0.374	/	/	/
Smoking history	0 = No, 1 = Yes	1.369	1.064-1.517	0.032	1.170	1.086-1.375	0.088
Drinking history	0 = No, 1 = Yes	0.994	0.704-1.328	0.584	/	/	/
Preoperative intestinal obstruction	0 = No, 1 = Yes	2.083	1.695-3.206	0.028	0.927	0.786-1.159	0.617
Preventive stoma	0 = No, 1 = Yes	1.046	0.903-1.254	0.438	/	/	/
Surgical time	0 = < 180 minutes, 1 = ≥ 180 minutes	1.098	0.916-1.328	0.330	/	/	/
Intraoperative bleeding	0 = < 300 mL, 1 = ≥ 300 mL	1.436	1.102-1.763	0.021	4.182	2.108-5.482	0.009
Neoadjuvant treatment	0 = No, 1 = Yes	1.121	0.921-1.328	0.287	/	/	/
Tumor size	0 = < 5 cm, 1 = ≥ 5 cm	0.899	0.711-1.197	0.319	/	/	/
TNM stage	0 = I, 1 = II or III	0.876	0.702-1.354	0.437	/	/	/
Tumor location	0 = ≥ 7 cm, 1 = < 7 cm	1.498	1.073-2.019	0.012	3.124	1.779-4.215	0.016
WBC	0 = < 10 × 109/L, 1 = ≥ 10 × 109/L	0.926	0.804-1.154	0.572	/	/	/
PLT	0 = < 400 × 109/L, 1 = ≥ 400 × 109/L	0.957	0.726-1.368	0.439	/	/	/
CRP	0 = < 10 mg/L, 1 = ≥ 10 mg/L	1.051	0.804-1.328	0.265	/	/	/

OR: Odds ratio; CI: Confidence interval; PA: Prealbumin; ALB: Albumin; TRF: Transferrin; BMI: Body mass index; TNM: Tumor node metastasis; WBC: White blood cell; Hb: Hemoglobin; PLT: Platelet; CRP: C-reactive protein.