Impact of open hepatectomy on postoperative bile leakage in patients with biliary tract cancer

Table 5 Risk factors for bile leak

Variables	Univariate analysis results	Multivariate analysis results
Age (> 60 yr)	OR 1.4, 95%CI: 0.6-3.2, P = 0.42
Sex (male)	OR 3.1, 95%CI: 1.2-7.9, P = 0.02	OR 2.6, 95%CI: 1.1-6.8, P = 0.03
BMI (> 25 kg/m2)	OR 1.3, 95%CI: 0.6-3.0, P = 0.51
ASA score (> II)	OR 1.8, 95%CI: 0.8-4.3, P = 0.16
Child-Pugh class (B)	OR 1.5, 95%CI: 0.5-4.7, P = 0.47
MELD score (> 10)	OR 1.7, 95%CI: 0.7-4.1, P = 0.24
Albumin (< 35 g/L)	OR 1.9, 95%CI: 0.8-4.5, P = 0.14
Total bilirubin (> 20 µmol/L)	OR 1.6, 95%CI: 0.7-3.8, P = 0.27
INR (> 1.1)	OR 1.4, 95%CI: 0.6-3.3, P = 0.44
Platelet count (< 150 × 109/L)	OR 1.2, 95%CI: 0.5-2.8, P = 0.66
Tumor type (HCC)	OR 4.3, 95%CI: 1.8-10.5, P < 0.01	OR 3.1, 95%CI: 1.4-7.2, P < 0.01
Tumor size (> 5 cm)	OR 1.9, 95%CI: 0.9-3.9, P = 0.09
Type of hepatectomy (major)	OR 5.6, 95%CI: 2.3-13.7, P < 0.01	OR 4.2, 95%CI: 1.9-9.4, P < 0.01
Blood loss (> 1000 mL)	OR 3, 95%CI: 1.2-7.4, P = 0.02	OR 2.7, 95%CI: 1.2-6.3, P = 0.02
Blood transfusion (yes)	OR 4, 95%CI: 1.6-10, P < 0.01	OR 3.4, 95%CI: 1.5-7.8, P < 0.01

ASA: American Society of Anesthesiologists; MELD: Model for End-Stage Liver Disease; INR: International normalized ratio; HCC: Hepatocellular carcinoma.