Role of Oncostatin M in the prognosis of inflammatory bowel disease: A meta-analysis

Table 1 Area under receiver operator curve values for the prediction of treatment outcomes by the Oncostatin M

Ref.	Prognostic association	OSM cutoff	AUC [95%CI]	Sensitivity [95%CI]	Specificity [95%CI]
Bertani et al[16], 2020	Prediction of no mucosal healing after anti-TNFα therapy at week 54 by baseline serum OSM	14	0.91 [0.81, 1]	96% [82, 100]	89% [67, 97]
Bertani et al[16], 2020	Prediction of no mucosal healing after anti-TNFα therapy at week 54 by serum OSM at week 14		0.83 [0.7, 0.95]
Bertani et al[17], 2022	Prediction of no mucosal healing after anti-TNFα therapy at week 54 by baseline serum OSM	14	0.91 [0.84, 0.99]	91% [78, 97]	90% [75, 97]
Bertani et al[17], 2022	Prediction of non-response to vedolizumab therapy at week 54 by baseline serum OSM		0.56 [0.42, 0.7]
Cao et al[18], 2021	Prediction of non-response to infliximab at week 54 by baseline fecal OSM		0.638
Cao et al[18], 2021	Prediction of non-response to infliximab at week 28 by baseline fecal OSM	132	0.763	66.7%	92.5%
Ezirike Ladipo et al[21], 2021	Prediction of response to anti-TNF therapy by OSM expression in biopsies	OSM expression in pre-treatment biopsies did not predict response to anti-TNF in a pediatric population
Mateos et al[22], 2021	Prediction of response to infliximab in a calprotectin log drop measurement model	OSM was found to have predicting ability to infliximab response
Minar et al[23], 2019	Prediction of no remission after anti-TNFα therapy at week 12 by baseline serum OSM	144	0.71 [0.52, 0.89]	71%	78%
Minar et al[23], 2019	Prediction of non-response to anti-TNFα therapy at week 12 by baseline serum OSM	117	0.69 [0.5, 0.89]
Mohamed et al[24], 2022	Prediction of no remission after anti-TNFα therapy by baseline serum OSM	119	0.56 [0.31, 0.82]	66.7%	54.2%
O’connell et al[26], 2022	Prediction of response to infliximab by colonic OSM expression	No association of pretreatment colonic OSM expression with outcomes of Infliximab therapy
Zhou et al[31], 2019	Prediction of the response to PF-00547659 (anti-human mucosal addressin cell adhesion molecule-1) therapy	Baseline OSM expression/levels were unable to predict response

AUC: Area under receiver operator curve; OSM: Oncostatin M; TNF: Tumor necrosis factor.