Predictive value of NLR, Fib4, and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma

Table 1 Baseline data for modeling queues and validation queues, n (%) or mean ± SD

Index		Total cases (n = 220)	Modeling queue (n = 154)	Validation queue (n = 66)	χ2	P value
Gender	Male	124 (56.36)	86 (55.84)	38 (57.58)	3.333	0.068
	Female	96 (43.64)	68 (44.16)	28 (42.42)
Age (yr)		53.11 ± 2.58	53.03 ± 3.98	52.98 ± 3.54	0.088	0.930
BMI (kg/m2)		21.26 ± 2.07	21.36 ± 2.36	21.28 ± 2.11	0.238	0.812
Smoking history	No	106 (48.18)	74 (48.05)	32 (48.48)	0.222	0.638
	Yes	114 (51.82)	80 (51.95)	34 (51.52)
Drinking history	No	114 (51.82)	79 (51.30)	35 (53.03)	0.346	0.556
	Yes	106 (48.18)	75 (48.70)	31 (46.97)
Hepatitis B	No	124 (56.36)	86 (55.84)	38 (57.58)	3.333	0.068
	Yes	96 (43.64)	68 (44.16)	28 (42.42)
Tumor diameter	< 5 cm	121 (55.00)	85 (55.19)	36 (54.55)	1.757	0.185
	≥ 5 cm	99 (45.00)	69 (44.81)	30 (45.45)
Liver cirrhosis	No	168 (76.36)	125 (81.47)	43 (65.15)
	Yes	52 (23.64)	29 (18.83)	23 (34.85)	0.346	0.556
Number of tumors	< 2	114 (51.82)	79 (51.30)	35 (53.03)
	≥ 2	106 (48.18)	75 (48.70)	31 (46.97)
Child-Pugh classification	Grade A	111 (50.45)	90 (58.44)	21 (31.82)	26.615	0.000
	Grade B	54 (24.55)	31 (20.13)	23 (34.85)
	Grade C	55 (25.00)	33 (21.43)	22 (33.33)
Surgical site	Left half liver	109 (49.55)	87 (56.49)	22 (33.33)	7.312	0.007
	Right half liver	67 (30.45)	33 (21.43)	34 (51.52)	19.842	0.000
	Bilateral hemiliver	44 (20.00)	34 (22.08)	10 (15.15)
AFP	< 400 μg/L	121 (55.00)	85 (55.19)	36 (54.55)	1.757	0.185
	≥ 400 μg/L	99 (45.00)	69 (44.81)	30 (45.45)
NLR		5.35 ± 3.23	5.36 ± 3.25	4.49 ± 2.55	1.934	0.054
Fib4		9.76 ± 2.53	9.72 ± 2.36	7.72 ± 3.42	4.999	0.000
APRI		0.58 ± 0.21	0.54 ± 0.22	0.53 ± 0.23	0.305	0.761

AFP: Alpha-fetoprotein; BMI: Body mass index; NLR: Neutrophil-lymphocyte ratio; Fib4: Fibrosis index based on four factors; APRI: Aspartate aminotransferase-to-platelet ratio index.