Risk factors for recurrence of common bile duct stones after surgical treatment and effect of ursodeoxycholic acid intervention

doi:10.4240/wjgs.v16.i1.103

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Jan 27, 2024 (publication date) through Nov 2, 2024

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World Journal of Gastrointestinal Surgery

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1948-9366

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Surg. Jan 27, 2024; 16(1): 103-112
Published online Jan 27, 2024. doi: 10.4240/wjgs.v16.i1.103

Table 4 Univariate analysis of recurrence of common bile duct stones after endoscopic retro-grade cholangiopancreatography

Variables		Non-recurrent group (n = 72)	Recurrent group (n = 28)	χ² value	P value
Age (yr, mean ± SD)		54.64 ± 6.62	51.43 ± 8.74	-1.983	0.050
Gender, n (%)	Male	31 (43.06)	13 (46.43)	0.093	0.760
	Female	41 (56.94)	15 (53.57)
Jaundice, n (%)	Yes	19 (26.39)	8 (28.57)	0.049	0.825
	No	53 (73.61)	20 (71.43)
Hypertension, n (%)	Yes	18 (25.00)	8 (28.57)	0.134	0.715
	No	54 (75.00)	20 (71.43)
Diabetes, n (%)	Yes	27 (37.50)	5 (17.86)	3.575	0.059
	No	45 (62.50)	23 (82.14)
History of biliary tract surgery, n (%)	Yes	12 (16.67)	2 (7.14)	1.519	0.218
	No	60 (83.33)	26 (92.86)
Parapillary diverticulum, n (%)	Yes	18 (25.00)	18 (64.29)	13.504	< 0.001
	No	54 (75.00)	10 (35.71)
No. of stones, n (%)	≤ 3	46 (63.89)	11 (39.29)	4.979	0.026
	> 3	26 (36.11)	17 (60.71)
Bile culture positive, n (%)		19 (26.39)	18 (64.29)	12.421	< 0.001
Postoperative treatment, n (%)	Control	26 (36.11)	21 (75.00)	12.240	< 0.001
	UDCA	46 (63.89)	7 (25.00)
Common bile duct diameter(mm), median (P₂₅, P₇₅)		14.00 (12.00, 15.00)	16.00 (14.00, 17.00)	-3.265	0.001
Maximum stone diameter(mm), median (P₂₅, P₇₅)		12.00 (11.25, 13.75)	15.00 (12.00, 16.00)	-3.599	< 0.001
ERCP time (min, mean ± SD)		63.93 ± 5.12	65.82 ± 5.33	1.640	0.140
WBC (× 10⁹/L, mean ± SD)		6.45 ± 1.05	6.38 ± 1.27	-0.290	0.772
PCT (ng/mL), median (P₂₅, P₇₅)		0.18 (0.12, 0.27)	0.18 (0.12, 0.28)	-0.088	0.930
TBiL (μmon/L, mean ± SD)		97.85 ± 10.95	97.32 ± 12.43	-0.211	0.833
DBiL (μmon/L, mean ± SD)		64.13 ± 7.64	62.02 ± 7.76	-1.234	0.220
GGT (U/L, mean ± SD)		330.90 ± 19.82	325.88 ± 21.99	-1.102	0.273
ALT (U/L, mean ± SD)		272.31 ± 22.87	269.09 ± 24.88	-0.617	0.538
ALP (U/L, mean ± SD)		259.81 ± 25.79	259.36 ± 23.50	-0.079	0.937
AST (U/L, mean ± SD)		201.12 ± 16.02	201.44 ± 15.55	0.089	0.929

ERCP: Endoscopic retro-grade cholangiopancreatography; UDCA: Ursodeoxycholic acid; WBC: White blood cell; PCT: Procalcitonin; TBiL: Total bilirubin; DBiL: Direct bilirubin; GGT: Gamma-glutamyl transferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; AST: Aspartate aminotransferase.

Citation: Yuan WH, Zhang Z, Pan Q, Mao BN, Yuan T. Risk factors for recurrence of common bile duct stones after surgical treatment and effect of ursodeoxycholic acid intervention. World J Gastrointest Surg 2024; 16(1): 103-112
URL: https://www.wjgnet.com/1948-9366/full/v16/i1/103.htm
DOI: https://dx.doi.org/10.4240/wjgs.v16.i1.103