Comparative detection of syndecan-2 methylation in preoperative and postoperative stool DNA in patients with colorectal cancer

Table 2 Demographic analysis of patients according to preoperative and postoperative syndecan-2 methylation test

Characteristics	Preoperative (n = 123)			Postoperative (n = 122)
	Negative, n = 14 (%)	Positive, n = 109 (%)	P value	Negative, n = 98 (%)	Positive, n = 24 (%)	P value
Sex			0.375			0.030
Male	11 (78.6)	69 (63.3)		68 (69.4)	11 (45.8)
Female	3 (21.4)	40 (36.7)		30 (30.6)	13 (54.2)
Age, yr			0.512			0.845
< 65	9 (64.3)	60 (55.0)		55 (56.1)	14 (58.3)
≥ 65	5 (35.7)	49 (45.0)		43 (43.9)	10 (41.7)
Location			0.664			0.079
Right colon	5 (35.7)	30 (27.5)		34 (34.7)	3 (12.5)
Left colon	7 (50.0)	51 (46.8)		42 (42.9)	12 (50.0)
Rectum	2 (14.3)	28 (25.7)		22 (22.4)	9 (37.5)
Histology			0.226			1.000
WD/MD	12 (85.7)	103 (94.5)		92 (93.9)	23 (95.8)
PD/Mucinous	2 (14.3)	6 (5.5)		6 (6.1)	1 (4.2)
Tumor size, cm			0.019			0.145
< 3	10 (71.4)	42 (38.5)		41 (41.8)	14 (58.3)
≥ 3	4 (28.6)	67 (61.5)		57 (58.2)	10 (41.7)
T stage			0.033			0.137
Tis-T2	9 (64.3)	34 (31.2)		33 (33.7)	12 (50.0)
T3-T4	5 (35.7)	75 (68.8)		65 (66.3)	12 (50.0)
N stage			0.769			0.152
N0	10 (71.4)	70 (64.2)		58 (59.2)	18 (75.0)
N+	4 (28.6)	39 (35.8)		40 (40.8)	6 (25.0)
TNM stage			0.769			0.152
0-II	10 (71.4)	70 (64.2)		58 (59.2)	18 (75.0)
III-IV	4 (28.6)	39 (35.8)		40 (40.8)	6 (25.0)
TCF before surgery			0.627			0.685
Not done	2 (14.3)	10 (9.2)		9 (9.2)	1 (4.2)
Done	12 (85.7)	99 (90.8)		89 (90.8)	23 (95.8)
RAA			0.692			0.172
Not present	13 (92.9)	94 (86.2)		88 (89.8)	19 (79.2)
Present	1 (7.1)	15 (13.8)		10 (10.2)	5 (20.8)

SDC2: Syndecan-2; WD: Well differentiated; MD: Moderately differentiated; PD: Poorly differentiated; TCF: Total colonoscopy; RAA: Remnant advanced adenoma.