Risk factors for myocardial injury during living donor liver transplantation in pediatric patients with biliary atresia

Table 4 Univariate and multivariate analyses of risk factors for myocardial injury during pediatric living donor liver transplantation

Factor	Univariate analysis OR (95%CI)	P value	Multivariate analysis OR (95%CI)	P value
Preoperative recipient-related data
Age	0.989 (0.974-1.003)	0.125
Male gender	1.081 (0.688-1.699)	0.735
Height	0.969 (0.951-0.988)	0.002	1.011 (0.964-1.060)	0.659
Weight	0.889 (0.827-0.955)	0.001	0.953 (0.800-1.136)	0.593
LVEF	1.044 (0.980-1.112)	0.178
QTc	0.999 (0.990-1.008)	0.774
PELD	1.074 (1.049-1.100)	< 0.001	1.065 (1.013-1.121)	0.014
ALT	1.001 (0.999-1.002)	0.540
AST	1.001 (1.000-1.002)	0.218
Total Bilirubin	1.004 (1.002-1.006)	< 0.001	1.001 (0.999-1.003)	0.353
INR	2.167 (1.435-3.272)	< 0.001	0.957 (0.554-1.653)	0.875
Creatinine	0.99 (0.951-1.031)	0.632
Hemoglobin	1.031 (0.897-1.184)	0.670
Vital signs immediately before reperfusion
HR	0.994 (0.977-1.012)	0.513
MAP	0.971 (0.949-0.993)	0.010	0.997 (0.971-1.023)	0.819
CVP	0.974 (0.896-1.057)	0.524
Temperature	1.088 (0.819-1.444)	0.560
Laboratory findings before reperfusion
pH	0.902 (0.032-25.155)	0.952
PCO2	0.971 (0.935-1.009)	0.129
PO2	0.999 (0.996-1.002)	0.478
Lactate	1.267 (1.092-1.469)	0.002	1.158 (0.990-1.355)	0.067
Base excess	0.946 (0.881-1.015)	0.122
Ca	0.374 (0.066-2.117)	0.266
K	0.857 (0.575-1.277)	0.447
Hemoglobin	0.836 (0.713-0.981)	0.029	0.956 (0.828-1.105)	0.544
Duration of anhepatic phase	1.019 (1.004-1.035)	0.016	1.021 (1.003-1.040)	0.025
Donor-related data
Cold ischemic time	1.006 (1.001-1.012)	0.016	1.003 (0.997-1.010)	0.334
Graft weight	0.999 (0.996-1.003)	0.755
PRS	2.260 (1.420-3.598)	0.001	1.966 (1.111-3.480)	0.020
The data at the end of the surgery
Duration of surgery	1 (0.998-1.002)	0.854
Duration of anesthesia	1.001 (0.999-1.003)	0.481
Blood loss	1.001 (1.000-1.002)	0.128
RBCs transfusion	1.151 (0.970-1.366)	0.107
FFP transfusion	1.002 (1.000-1.004)	0.017	1.001 (0.999-1.003)	0.441

LVEF: Left ventricular ejection fraction; PELD: Pediatric end-stage liver disease; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; INR: International normalized ratio; MAP: Mean arterial pressure; CVP: Central venous pressure; PRS: Postreperfusion syndrome; RBCs: Red blood cells; FFP: Fresh frozen plasma.