Short- and long-term results of open vs laparoscopic multisegmental resection and anastomosis for synchronous colorectal cancer located in separate segments

Table 3 Univariate and multivariate analysis of overall survival and disease-free survival

Variable	Overall survival				Disease-free survival
	Univariable analysis		Multivariate analysis		Univariable analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value	HR (95%CI)	P value
Age (> 65/≤ 65 yr)	2.830 (0.983-8.150)	0.054	2.378 (0.793-7.128)	0.122	2.048 (0.779-5.384)	0.146	1.869 (0.674-5.188)	0.230
Gender (male/female)	1.051 (0.382-2.894)	0.923			1.180 (0.436-3.191)	0.744
CEA level (> 5/≤ 5)	1.278 (0.389-4.198)	0.686			1.098 (0.348-3.465)	0.873
CA19-9 level (> 37/≤ 37)	1.951 (0.506-7.521)	0.332			1.304 (0.285-5.958)	0.732
ASA physical status (III/I-II)	2.565 (0.817-8.050)	0.106			2.280 (0.655-7.940)	0.195
Tumor differentiation (poor/well- moderate)	0.918 (0.340-2.478)	0.866			1.119 (0.431-2.906)	0.817
Tumor size (> 5/≤ 5 cm)	1.058 (0.383-2.920)	0.913			0.863 (0.328-2.269)	0.764
T stage (T3-T4/T1-T2)	0.994 (0.130-7.627)	0.994			1.302 (0.172-9.854)	0.798
N stage (N1-N2/N0)	11.266 (1.487-85.384)	0.019	10.161 (1.327-77.790)	0.026	13.414 (1.775-101.359)	0.012	13.107 (1.719-99.925)	0.013
Operative approach (LMRA/OMRA)	1.240 (0.426-3.611)	0.693	0.834 (0.274-2.534)	0.749	1.233 (0.432-3.516)	0.695	0.812 (0.269-2.454)	0.712

OMRA: Open multisegmental resection and anastomosis; LMRA: Laparoscopic multisegmental resection and anastomosis; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; ASA: American Society of Anesthesiologists; HR: Hazard ratio; CI: Confidence interval.