High spindle and kinetochore-associated complex subunit-3 expression predicts poor prognosis and correlates with adverse immune infiltration in hepatocellular carcinoma

Figure 7 Association between the spindle and kinetochore-associated complex subunit 3 expression level and immune microenvironment factors in hepatocellular carcinoma. A: Correlation analysis between spindle and kinetochore-associated complex subunit 3 (SKA3) expression and the infiltration levels of 7 tumor-infiltrating immune cells as assessed via the Tumor Immune Estimation Resource database; B: Proportions of 24 types of infiltrating immune cells in the groups with low and high expression of SKA3 determined by single-sample Gene Set Enrichment Analysis; C: Correlation heatmap of the 24 immune cell types; D: Scatter plot. The fitted line showed the relationship between SKA3 expression and immune checkpoint inhibitors (programmed cell death protein 1, cytotoxic T lymphocyte antigen 4). SKA3: Spindle and kinetochore-associated complex subunit 3; HCC: Hepatocellular carcinoma; TIICs: Tumor-infiltrating immune cells; PDCD-1: Programmed cell death protein 1; CTLA-4: Cytotoxic T lymphocyte antigen 4. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.